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MTMR9 encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain.
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Polymorphism of rs2293855 in MTMR9 is associated with measures of glucose tolerance, indices of insulin (show INS ELISA Kits) secretion and indices of insulin (show INS ELISA Kits) sensitivity.
MTMR6, which dephosphorylates PI(3 (show PI3 ELISA Kits))P to PI, and its binding partner MTMR9, are required for macropinocytosis.
Our data suggest that genetic variations in the FTO (show FTO ELISA Kits), SCG3 (show SCG3 ELISA Kits) and MTMR9 genes independently influence the risk of metabolic syndrome.
Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.
MTMR9 greatly enhances the functions of MTMR6
MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins (show INS ELISA Kits)(1,3)P2 in neuronal cells.
This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
myotubularin related protein 8
, myotubularin-related protein 9
, myotubularin related protein 9
, myotubularin-related protein 9-like