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The protein encoded by MX2 has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases.
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Human Polyclonal MX2 Primary Antibody for IHC, IHC (p) - ABIN4336862
Kane, Yadav, Bitzegeio, Kutluay, Zang, Wilson, Schoggins, Rice, Yamashita, Hatziioannou, Bieniasz: MX2 is an interferon-induced inhibitor of HIV-1 infection. in Nature 2013
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The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.
MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. [review]
These experiments suggested that MxB does not contribute to the HIV-1 restriction observed in IFN-alpha (show IFNA Antibodies)-treated human cells.
Together, the data demonstrate that interferon-beta inhibits foamy virus early in infection and that MxB is not a restriction factor of foamy virus.
We propose that lower-order oligomerization of MX2 is sufficient for the effective inhibition of human immunodeficiency virus type 1.
Study analyzed the evolutionary history of MX2 at the inter- and intraspecific level and use this information to identify a haplotype that associates with natural resistance to HIV-1 infection in humans; the ancestral (G) allele of rs2074560 protects from HIV-1 infection with a recessive effect.
The high prevalence of MxB-resistant mutations in the CypA-binding loop indicates the significant selective pressure of MxB on HIV-1 replication in vivo.
MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes.
HIV-seronegative women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV resistance.
MxB oligomerization is important for the ability of MxB to bind to the HIV-1 core proteins.
MX1 (show MX1 Antibodies)-a, MX1B (show MX1 Antibodies) and MX2 are affected by the type I IFN pathway during pregnancy and are involved in an immune response to protect the mother and fetus
Data indicate that the expression profiles of ISG15 (show ISG15 Antibodies), MX1 (show MX1 Antibodies), MX2, and OAS1 (show OAS1 Antibodies) could be a useful diagnostic biomarker of gestation.
A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.
Expression of Mx protein and interferon-alpha (IFN-alpha (show IFNA Antibodies)) was examined by immunohistochemistry in pigs experimentally infected with swine influenza virus.
The porcine Mx1 (show MX1 Antibodies) gene and promoter share the major structural and functional characteristics displayed by their homologs described in cattle, mouse, chicken, and man.
The 341-bp MX2 promoter region contained regulatory sequences for ISRE, GC box, Sp1 (show SP1 Antibodies) and AP-1 (show JUN Antibodies), as well as a TATA box. Nucleotide sequences of the MX2 promoter region revealed four substitutions and one deletion, in which six genotypes were classified.
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.
interferon-induced GTP-binding protein Mx2
, myxovirus resistance protein 2
, interferon-induced GTP-binding protein Mx3
, myxovirus (influenza virus) resistance 3
, myxovirus resistance protein 3
, interferon-regulated resistance GTP-binding protein MXB
, p78-related protein
, second interferon-induced protein p78
, Mx protein
, myxovirus (influenza virus) resistance 2 , interferon-inducible protein p78
, GTP-binding protein Mx2
, myxovirus resistance 2