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The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Additionally we are shipping Nescient Helix Loop Helix 1 Antibodies (47) and Nescient Helix Loop Helix 1 Kits (16) and many more products for this protein.
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The polymorphism was further reproducibly associated with a DNA methylation signature in whole blood (P = 4.5x10-40) that also associated with allergic sensitization and expression in blood of the cytokine TSLP (P = 1.1x10-4). Knockdown of the transcription factor predicted to bind the enhancer region (NHLH1) in a human cell line (HEK293) expressing NHLH1 resulted in lower TSLP expression
This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding nescient helix-loop-helix 1.
expression of NSCL-1 and NSCL-2 in the developing central and peripheral nervous system, most likely in developing neurons.
These results demonstrate that NeuroD1 is an upstream regulator of the NSCL1 gene but not the NSCL2 gene in mice.
Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice.
expression in the olfactory epithelium (OE) and the vomeronasal organ (VNO) during development; may function during development rather than in the adult stage
Data show that NSCL-1 and -2, together with additional cofactors, directly control transcription of the necdin gene.
We conclude that NSCL-1/2 maintain migration and survival of cells in the migratory stream to the cerebellum.
The mouse homolog of HEN1 is expressed specifically in testis and methylates 3' termini of Piwi-interacting RNAs in vitro.
Insm1 and Nhlh1/NSCL1 are novel HH targets induced by Shh treatment in cultured cerebellar granule cell progenitors.
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).
nescient helix loop helix 1
, transcription factor XHEN1
, class A basic helix-loop-helix protein 35
, helix-loop-helix protein 1
, HELIX-LOOP-HELIX PROTEIN 1 (HEN1) (NSCL)