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NCDN encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Additionally we are shipping Neurochondrin Antibodies (61) and Neurochondrin Kits (12) and many more products for this protein.
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Schizophrenia subjects compared to controls showed a marked increase in CA1 (show CA1 Proteins) hippocampal Norbin, and Tamalin (show GRASP Proteins) proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 (show GRM5 Proteins) signalling and trafficking
we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5 (show RAB5A Proteins)-positive endosomes.
In mouse, the encoded protein is a negative regulator of Ca/calmodulin-dependent protein kinase II phosphorylation and is essential for the spatial learning process.
A novel mechanism of P-Rex1 regulation through the GPCR (show GPBAR1 Proteins)-adaptor protein Norbin.
Norbin is a regulator of adult hippocampal neurogenesis and that its deletion causes depressive-like behaviors.
study reports that Norbin, a neuron-specific protein, physically interacts with mGluR5 (show GRM5 Proteins) in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 (show GRM5 Proteins) signaling
neurochondrin/norbin gene function is essential for the early embryogenesis
Neurochondrin expression pattern in the developing and adult brain.
results showed that neurochondrin is a negative regulator of Ca(2+)/calmodulin-dependent protein kinase II phosphorylation and specific homozygous gene disruption resulted in epileptic seizure
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.
, neurochondrin homolog
, M-Sema F-associating protein of 75 kDa
, minisatellite 10ae detected by probe MMS10
, neurite outgrowth-related protein from the rat brain