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NGB encodes an oxygen-binding protein that is distantly related to members of the globin gene family. Additionally we are shipping Neuroglobin Antibodies (94) and Neuroglobin Kits (66) and many more products for this protein.
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Human Neuroglobin Protein expressed in Wheat germ - ABIN1312525
Powers: p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy. in Journal of neuropathology and experimental neurology 2006
Results show that the expression of NGB (show GTPBP4 Proteins) in glioma is grade related and is negatively regulated at the transcriptional level by PPARgamma (show PPARG Proteins) suggesting an important role of NGB (show GTPBP4 Proteins) in glioma progression.
The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb (show GTPBP4 Proteins) are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb (show GTPBP4 Proteins).
Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning
these results highlight the involvement of ERa activation and of E2/ERa-dependent NGB (show GTPBP4 Proteins) upregulation in the insensitivity of MCF-7 to paclitaxel. These novel findings could have important implications in the development of targeted therapeutics for overcoming paclitaxel insensitivity in ERa-positive human breast cancer
Knockdown of GATA-2 (show GATA2 Proteins) caused NGB (show GTPBP4 Proteins) expression to drop dramatically, indicating GATA-2 (show GATA2 Proteins) as an essential transcription factor for the activation of NGB (show GTPBP4 Proteins) expression via binding to a novel distal regulatory element of NGB (show GTPBP4 Proteins).
analysis of how the interaction of hydrogen sulfide (show SQRDL Proteins) with human neuroglobin is muted (show MUTED Proteins) by a distal ligand
NO oxidation kinetics at physiological NO concentrations. The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB (show GTPBP4 Proteins) showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB (show GTPBP4 Proteins), which is the redox active form of the protein in contrast to oxy (show GCG Proteins)-NGB (show GTPBP4 Proteins).
Taken together, this work support the first evidence that Ngb (show GTPBP4 Proteins) can be potentially used as a promising biomarker and target for novel treatment of human glioma
The (show GTPBP4 Proteins) cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb. Within the human SOC, many medial superior olive neurons, and scattered neurons in the LSO, were Ngb-immunoreactive
Study characterized the presence of Ngb (show GTPBP4 Proteins) in the human cochlea
NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model.
Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability.
Ngb can bind to mitochondrial complex III subunit Cyc1 (show CYC1 Proteins), leading to suppression of oxygen-glucose deprivation -mediated complex III activity.
Reduction of Ngb expression in mouse retina after optic nerve injury.Ngb role in neuroregeneration in mice after optic nerve injury.
Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator.
Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC (show UBXN11 Proteins)) also express considerable amounts of Ngb.
Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK (show PRKAA1 Proteins) signaling.
Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury.
Overexpression of neuroglobin reduced sensorimotor deficits following TBI. An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI may improve recovery.
Constitutive expression levels of neuroglobin in neonatal brain cells may explain mild neuronal injury after 60 min. of deep hypothermic circulatory arrest.
The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
Chimeric Myoglobin (show MB Proteins) has a cell-membrane-penetrating activity similar to zebrafish Ngb.
Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin (show MB Proteins)-like function of this protein in facilitated oxygen diffusion
both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
Ngb overexpression may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic spinal cord injury
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.