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NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]..
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ectopic expression of miR (show MLXIP Proteins)-744 and miR (show MLXIP Proteins)-224 during neural differentiation resulted in downregulation of endogenous Npas4 expression.
Using a series of behavioral, molecular, pharmacological and genetic approaches in mice, study shows that deficiency in Npas4 affects adolescent expression of multiple markers of GABAergic transmission in the PFC (show CFP Proteins), including parvalbumin (show PVALB Proteins) and GAD67 (show GAD1 Proteins), in a sex-specific manner. Abnormal pattern of expression of GABAergic markers is associated with sex-specific and age-dependent cognitive and emotional impairments.
The findings of this study suggest that Npas4 may be involved in post-stroke psychiatric changes related to anxiety ad sociability.
NPAS4 is expressed in endothelial cells, regulates VE-cadherin (show CDH5 Proteins) expression and regulates sprouting angiogenesis.
These findings suggest that 11beta-HSD1 (show HSD11B1 Proteins) may contribute to the decline in Npas4 and Arc (show NOL3 Proteins) mRNA levels associated with memory impairment during ageing
beta cell cytotoxicity of the calcineurin inhibitor (show RCAN1 Proteins) and immunosuppressant tacrolimus (FK-506) was prevented by Npas4 overexpression.
Results suggest that transcription of the Npas4 gene is downregulated by stress through DNA methylation (show HELLS Proteins) of its promoter
induction of Npas4 identifies the area influenced by cortical spreading depression propagation.
Cortex activation by sensory conditioning was found to upregulate the expression of both Npas4 and c-Fos.
Data showed that differential levels of Npas4 expression in the brain may regulate anxiety, depression and cognition related disorders.
This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review]
we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain
These results provide insight into the mechanisms of NPAS4/ARNT (show ARNT Proteins) dimerisation and transcriptional activation.
a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 (show SIM2 Proteins) in the mental retardation of Down's syndrome
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2\; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004
HLH-PAS transcription factor NXF
, bHLH-PAS type transcription factor NXF
, limbic-enhanced PAS protein
, neuronal PAS domain-containing protein 4
, neuronal PAS4
, bHLH PAS type transcription factor NXF
, PAS domain-containing protein 10
, class E basic helix-loop-helix protein 79
, neuronal PAS domain protein 4
, neuronal PAS domain-containing protein 4-like