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The protein encoded by OGFR is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin.
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Morphine interacts with OGFR and may suppress lung cancer proliferation and progression.
The blockade of OGF (show PENK Proteins) signaling by MNTX releases cells from their arrest and boosts the effect of Doc
The OGF (show PENK Proteins)-OGFr axis may be a feasible target for treatment of cancer of the ovary (i) in a prophylactic fashion, (ii) following cytoreduction or (iii) in conjunction with standard chemotherapy for additive effectiveness
OGF (show PENK Proteins)-OGFr axis is a determinant of the progression of human ovarian cancer
OGF (show PENK Proteins) and OGFR are present in follicular-derived thyroid cancers, and that OGF (show PENK Proteins) serves in a inhibitory manner to maintain homeostasis of cell proliferation.
Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers.
Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers
These data indicate that the OGF (show PENK Proteins) receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias.
supports opioid growth factor receptor (OGFr) gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer.
Results indicate that both p16(INK4a) and p21(WAF1/CIP1 (show CDKN1A Proteins)) are required for the opioid growth factor (OGF)-OGF (show PENK Proteins) receptor axis to inhibit cell proliferation in normal cells.
These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair.
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as
, opioid growth factor receptor
, 7-60 protein
, protein 7-60
, zeta-type opioid receptor