Opioid Growth Factor Receptor Proteins (OGFR)

Human Opioid Growth Factor Receptor (OGFR) interaction partners

1. Morphine interacts with OGFR and may suppress lung cancer proliferation and progression.

2. The blockade of OGF signaling by MNTX releases cells from their arrest and boosts the effect of Doc

3. The OGF-OGFr axis may be a feasible target for treatment of cancer of the ovary (i) in a prophylactic fashion, (ii) following cytoreduction or (iii) in conjunction with standard chemotherapy for additive effectiveness

4. OGF-OGFr axis is a determinant of the progression of human ovarian cancer

5. These data are the first to report that theOGFr system is a native biological regulator of cell proliferation in Hepatocellular carcinoma

6. OGF and OGFR are present in follicular-derived thyroid cancers, and that OGF serves in a inhibitory manner to maintain homeostasis of cell proliferation.

7. Gene therapy to reinstate more OGFr and enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression in head and neck cancers.

8. Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers

9. These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias.

10. supports opioid growth factor receptor (OGFr) gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer.

11. Results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the opioid growth factor (OGF)-OGF receptor axis to inhibit cell proliferation in normal cells.

12. the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors.

13. Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.

14. Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers.

Mouse (Murine) Opioid Growth Factor Receptor (OGFR) interaction partners

1. These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair.