Pannexin 1 Proteins (PANX1)

The protein encoded by PANX1 belongs to the innexin family. Additionally we are shipping Pannexin 1 Antibodies (63) and Pannexin 1 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PANX1 24145 Q96RD7
PANX1 55991 Q9JIP4
PANX1 315435 P60570
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Top Pannexin 1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$762.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

PANX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Pannexin 1 Proteins

  1. Human PANX1 Protein expressed in Wheat germ - ABIN1313962 : Seike, Takehara, Kobayashi, Nagahama: Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death. in Biochimica et biophysica acta 2016 (PubMed)

More Proteins for Pannexin 1 (PANX1) Interaction Partners

Zebrafish Pannexin 1 (PANX1) interaction partners

  1. Extracellular ATP hydrolysis via NTPDase1 (show ENTPD1 Proteins) action inhibits synaptic transmission by pannexin 1-mediated increase in pH buffering of the synaptic cleft.

  2. The existence of two Panx1 proteins in zebrafish displaying distinct tissue distribution, protein modification and electrophysiological properties, suggests that both proteins fulfill different functions in vivo.

  3. The function of panx1 channel is significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region of panx1.

Human Pannexin 1 (PANX1) interaction partners

  1. Progressive PANX1 channel opening is directly linked to permeation of ions and large and occurs during both irreversible and reversible forms of channel activation. This unique, quantized activation process enables fine tuning of PANX1 channel activity and may be a generalized regulatory mechanism for other related multimeric channels.

  2. authors proposed a tentative intracellular signaling pathway of the acetylcholine-induced ciliary beat, in which the pannexin-1-purinergic P2X receptor unit may play a central role in ciliary beat regulation

  3. These results newly identify Pannexin-1 as a protein highly expressed in human dermal lymphatic endothelial cells.

  4. The pannexin 2 (Panx2 (show PANX2 Proteins)) N86Q mutant is glycosylation-deficient and tends to aggregate in the endoplasmic reticulum (ER)reducing its cell surface trafficking but it can still interact with pannexin 1 (Panx1).

  5. All three pannexins Panx1, Panx2 (show PANX2 Proteins), and Panx3 (show PANX3 Proteins) mRNAs were expressed in all of the analyzed undifferentiated stem cell lines.

  6. Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling.

  7. The ubiquitous expression, as well as its function as a major ATP release and nucleotide permeation channel, makes Panx1 a primary candidate for participating in the pathophysiology of CNS disorders.

  8. Panx1 was mainly distributed in microcolumn neurons, dysmorphic neurons, balloon cells and reactive astrocytes in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.

  9. ATP release from red blood cells is not mediated by the cAMP-mediated Panx1 pathway.

  10. Panx1 channels are involved in beta-toxin-induced cell death.

Mouse (Murine) Pannexin 1 (PANX1) interaction partners

  1. Panx1 expressed in immune cells is critical for pain-like effects following nerve injury in mice, perhaps via a GPCR (show GPBAR1 Proteins)-mediated activation mechanism, and suggest that inhibition of Panx1 may be useful in treating neuropathic pain.

  2. Auditory brainstem response thresholds in the Gen-Panx1 KO mouse were significantly increased. Distortion product otoacoustic emission and cochlear microphonics were significantly reduced.

  3. These novel findings reveal unique roles for GFAP (show GFAP Proteins)-positive glial and neuronal Panx1 and describe new chronic pain targets for cell-type specific intervention in this often intractable disease.

  4. Panx-1 modulation may be interesting to amplify the clinical effect of cisplatin (DDP (show TIMM8A Proteins)) and reverse the resistance of testicular cancer cells to DDP (show TIMM8A Proteins).

  5. Pannexin1 may play a role in the pathogenesis of liver disease.

  6. Findings indicate a deleterious role for membrane channel Pannexin 1 (Panx1) in response to permanent permanent middle cerebral artery (MCA (show RSPH1 Proteins)) occlusion, that is unique to females.

  7. ATP release from red blood cells is not mediated by the cAMP-mediated Panx1 pathway.

  8. blocking Panx1 and/or Casp4 (show CASP4 Proteins) activities is a beneficial strategy to enhance donor cell engraftment and LG regeneration through the reduction of inflammation.

  9. found a significant increase in waking and a correspondent decrease in slow wave sleep percentages in the Panx1-/- animals.

  10. Diabetic C57BL/6J-Ins2Akita mice were used to evaluate in vivo effects of high glucose on P2R and Panx1

Pannexin 1 (PANX1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.

Gene names and symbols associated with Pannexin 1 Proteins (PANX1)

  • pannexin 1a (panx1a)
  • pannexin 1 (PANX1)
  • pannexin 1 (panx1)
  • pannexin 1 (Panx1)
  • Pannexin 1 (Panx1)
  • AI847747 protein
  • MRS1 protein
  • Pannexin-1 protein
  • pannexin1 protein
  • PANX1 protein
  • PX1 protein
  • UNQ2529 protein
  • zgc:55631 protein

Protein level used designations for Pannexin 1 Proteins (PANX1)

pannexin 1 , pannexin-1 , innexin

GENE ID SPECIES
393890 Danio rerio
466751 Pan troglodytes
697204 Macaca mulatta
772164 Gallus gallus
100014304 Monodelphis domestica
100170473 Xenopus (Silurana) tropicalis
100171730 Pongo abelii
24145 Homo sapiens
607532 Canis lupus familiaris
528169 Bos taurus
55991 Mus musculus
315435 Rattus norvegicus
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