Plakophilin 1 Proteins (PKP1)

PKP1 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Additionally we are shipping Plakophilin 1 Antibodies (72) and Plakophilin 1 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PKP1 18772 P97350
Rat PKP1 PKP1 304822  
PKP1 5317 Q13835
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Top Plakophilin 1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days

PKP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,

More Proteins for Plakophilin 1 (PKP1) Interaction Partners

Mouse (Murine) Plakophilin 1 (PKP1) interaction partners

  1. PKP1 has roles in desmosome and tight junction function and in growth control, a function that is crucial in wound healing and epidermal carcinogenesis

  2. This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation.

Human Plakophilin 1 (PKP1) interaction partners

  1. These results implicate the participation of PKP1 in early tooth morphogenesis as an effector of canonical Wnt signaling that controls ameloblast differentiation via regulation of the cell adhesion complex

  2. Collectively, altered expression of PKP1 and SPOCK1 appears to be a frequent and critical event in prostate cancer

  3. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.

  4. Plakophilin-1 has a role in protecting keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes

  5. Data indicate that upon activation of growth factor signaling, plakophilin 1 switches from a desmosome-associated growth-inhibiting to a cytoplasmic proliferation-promoting function.

  6. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased

  7. PKP1 loss secondary to promoter methylation, as well as other mechanisms, may promote the progression of Barrett's esophagus to esophageal adenocarcinoma in a subset of patients via decreased desmosome assembly and increased cell motility

  8. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype

  9. in addition to mediating desmosome assembly, the nuclear pool of Pkp can influence cell survival by interactions with DNA

  10. These findings identify PKP1 as a regulator of translation and proliferation via modulation of eIF4A1 activity.

  11. the clinicopathologic features attest to the significant role of PKP1 in stabilization of desmosome structure and function, predominantly in the spinous layers of the epidermis

  12. Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1. Homozygous intron 11 donor splice site mutation in the plakophilin 1 gene, 2021+1 G>A.

  13. The PKP1 null patients showed poorly developed inner and outer desmosomal plaques and reductions in the lower suprabasal layer desmosome size and number so pkp1 has a recruiting and stabilizing role in desmosome formation

  14. plakophilin 1 has a key role in increasing desmosomal protein content, in desmosome assembly, and in regulating cell migration

  15. crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes

  16. Co-expression of a classical cadherin (N-cadherin) and plakophilin-1/ER in A431D cells resulted in punctate desmoplakin staining at cell-cell borders

  17. Compound heterozygosity for new splice site mutations in the plakophilin 1 gene (PKP1) in a Chinese case of ectodermal dysplasia-skin fragility syndrome

  18. the Plakophilin-1 carboxyl terminus recruits it to plasma membrane, whereas amino terminus recruits desmoplakin and promotes desmosome assembly

  19. The Ki67+ proliferation index was inversely correlated with desmoplakin and plakophilin-1 during cervical squamous cell carcinogenesis

  20. Loss of plakophilin-1 expression during head and neck squamous cell carcinoma (HNSCC) progression may contribute to an invasive phenotype.

Plakophilin 1 (PKP1) Protein Profile

Protein Summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Plakophilin 1 Proteins (PKP1)

  • plakophilin 1 (PKP1)
  • plakophilin 1b (pkp1b)
  • plakophilin 1 (Pkp1)
  • AI528551 protein
  • B6P protein
  • fb30d08 protein
  • PKP1 protein
  • wu:fb30d08 protein

Protein level used designations for Plakophilin 1 Proteins (PKP1)

plakophilin 1 , plakophilin-1 , band 6 protein , B6P , armadillo , band 6 , band-6 protein

708177 Macaca mulatta
797838 Danio rerio
18772 Mus musculus
304822 Rattus norvegicus
100338080 Oryctolagus cuniculus
421158 Gallus gallus
5317 Homo sapiens
281405 Bos taurus
100733998 Cavia porcellus
101109291 Ovis aries
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