anti-Pleiomorphic Adenoma Gene 1 (PLAG1) Antibodies

Human Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. The presence of PLAG1 fusion was associated with specific histological features in pleomorphic adenoma

2. PLAG1 and USF2 cooperation is thus an important contributor to stem cell-specific expression of MSI2 and hematopoietic stem and progenitor cell-specific transcriptional circuitry.

3. Rearrangement of PLAG1 and HMGA2 and expression of the corresponding proteins are frequent and specific findings in lacrimal gland pleomorphic adenoma (PA) and ca-ex-PA.

4. PLAG1 is a microRNA target gene that is overexpressed in Wilms tumors with mutations in microRNA processing genes.

5. HRAS mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 and HMGA2 correlates with the presence of TP53, FBXW7 mutations, or SMARCB1 deletion.

6. Plag1 expression is lost in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.

7. MiR-26a can facilitate occurrence of pituitary tumor and invasiveness, probably via inhibiting PLAG1 expression.

8. expression of PLAG1 can be considered a valuable diagnostic marker for recurrent pleomorphic adenoma

9. High PLAG1 expression is associated with pleomorphic adenoma.

10. The sensitivity (55%) and specificity (75%) of PLAG1 in diagnosing PA in FNAs is relatively modest thus limiting its diagnostic utility.

11. The Thr34 of PLAG1 is critical for LpMab-10 recognition.

12. Data indicate that SLIT2, miR-218-1, RET/PLAG1 and SLIT2/ROBO1 pathway involved in Hirschsprung's disease.

13. Altogether, these data suggest that HMGA2 is an upstream activator of PLAG1.

14. Report illustrates two different tumorigenic pathways implicating PLAG1 in lipoblastoma: amplification through multiple copies of a small marker chromosome derived from chromosome 8, and a paracentric inversion of the long arm of chromosome 8. Review.

15. The nuclear import of PLAG1 by KPNA2 is essential for the role of KPNA2 in HCC cells.

16. a marker with good specificity for salivary gland pleomorphic adenomas

17. Extraskeletal myxoid chondrosarcoma of the vulva with PLAG1 gene activation: molecular genetic characterization of 2 cases

18. Fluorescence in situ hybridization for PLAG1 or HMGA2 can be used to distinguish between pleomorphic adenoma and carcinoma ex-pleomorphic adenoma and their morphologic mimics.

19. lipoblastoma is a group of lipomatous tumors with PLAG1 rearrangement and overexpression.

20. These results suggest that PLAG1 and CYLD do not play a role in ACC tumorigenesis.

Cow (Bovine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16(th) and 18(th) centuries

2. The selection of PLAG1 gene could be used to ensure the breeding direction for growth traits of the beef cattle.

3. The Indel marker of PLAG1 gene can be used as candidate molecular markers for the breeding in cattle.

4. Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank Weight in Simmental Beef Cattle.

5. A region of reduced heterozygosity surrounds the C allele; this is small in B. taurus but 20 Mb long in Brahmans, indicating recent and strong selection for the mutant allele.

6. Its genetic variation influences body weight gain and body size of cattle.

7. This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.

Mouse (Murine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. PLAG1 deficiency does not have a major impact on the reproductive control by the hypothalamo-pituitary system.

2. Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility.

3. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances.

4. Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas.

5. Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions

6. aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.

7. Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development.

8. Suggest an important role for furin in PLAG1-induced salivary gland tumorigenesis in mice.

9. results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt signaling

Pig (Porcine) Pleiomorphic Adenoma Gene 1 (PLAG1) interaction partners

1. NR6A1, PLAG1 and VRTN are significantly associated with the number of vertebrae in Chinese Tongcheng x Large White crossbred pigs

2. distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 as strong candidate genes on SSC7 and SSC4, respectively.