Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 Proteins (KCNN4)

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Additionally we are shipping KCNN4 Antibodies (85) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNN4 3783 O15554
Rat KCNN4 KCNN4 65206  
KCNN4 16534 O89109
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Top KCNN4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details

KCNN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaction Partners

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blockade of K(Ca)3.1 by delivery of TRAM (show TRAM1 Proteins)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. present study was designed to evaluate in hereditary xerocytosis the functional link between mutated Piezo1 (show PIEZO1 Proteins) and KCNN4

  2. this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.

  3. Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.

  4. KCa3.1 channels are important modulators in hepatocellular homeostasis.

  5. Tumor suppressor miR (show MLXIP Proteins)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.

  6. We identified a two-gene signature including KCNN4 and S100A14 (show S100A14 Proteins) which was related to recurrence in optimally debulked serous ovarian carcinoma patients

  7. Human arrhythmogenic calmodulin mutations impede the activation of SK2 (show KCNN2 Proteins) channels in human embryonic kidney 293 cells.

  8. This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.

  9. Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (show TRPC1 Proteins) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.

  10. Higher epithelial KCNN4 expression was closely correlated with advanced TNM (show ODZ1 Proteins) stages and predicted a poor prognosis in patients with pancreatic ductal adenocarcinoma.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) interaction partners

  1. Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (show GJA4 Proteins) and IK1 expression may contribute. nNOS (show NOS1 Proteins) or iNOS (show NOS2 Proteins) did not upregulate to compensate for decreased eNOS (show NOS3 Proteins), and they had little involvement in vasomotor function.

  2. The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.

  3. KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.

  4. KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (show TICAM2 Proteins)-34.

  5. SK4 activity is crucial for cell cycle control.

  6. Following differentiation with LPS (show TLR4 Proteins) or a combination of LPS (show TLR4 Proteins) and IFN-gamma (show IFNG Proteins) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (show CSN3 Proteins) 3.1 and Kir (show GEM Proteins) currents, while microglia differentiated with IL-4 (show IL4 Proteins) exhibited large Kir (show GEM Proteins) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (show CSN3 Proteins) 3.1 currents were generally low

  7. Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.

  8. Dynamic coupling between TRPV4 (show TRPV4 Proteins) and Ca(2 (show CA2 Proteins)+)-activated SK1 (show SPHK1 Proteins)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (show KCNMA1 Proteins) in kidney collecting duct cells.

  9. Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.

  10. enhanced KCa (show CSN3 Proteins) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.

KCNN4 Protein Profile

Protein Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Gene names and symbols associated with KCNN4

  • potassium calcium-activated channel subfamily N member 4 (KCNN4)
  • potassium calcium-activated channel subfamily N member 4 (Kcnn4)
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4)
  • hIKCa1 protein
  • hKCa4 protein
  • hSK4 protein
  • IK1 protein
  • IKCA1 protein
  • KCa3.1 protein
  • KCA4 protein
  • mIKCa1 protein
  • rKCNN4c protein
  • rSK4 protein
  • SK4 protein
  • SKCas protein

Protein level used designations for KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID SPECIES
397081 Sus scrofa
456098 Pan troglodytes
100379254 Cavia porcellus
100391934 Callithrix jacchus
100468357 Ailuropoda melanoleuca
100593199 Nomascus leucogenys
3783 Homo sapiens
65206 Rattus norvegicus
534591 Bos taurus
484464 Canis lupus familiaris
16534 Mus musculus
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