Protein Geranylgeranyltransferase Type I, beta Subunit Proteins (PGGT1B)

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). Additionally we are shipping Protein Geranylgeranyltransferase Type I, beta Subunit Antibodies (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PGGT1B 5229 P53609
PGGT1B 81746 P53610
PGGT1B 225467 Q8BUY9
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Top Protein Geranylgeranyltransferase Type I, beta Subunit Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,036.00
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,036.00
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PGGT1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Protein Geranylgeranyltransferase Type I, beta Subunit (PGGT1B) Interaction Partners

Human Protein Geranylgeranyltransferase Type I, beta Subunit (PGGT1B) interaction partners

  1. our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion

  2. our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability

  3. RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.

  4. results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion

  5. Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.

Mouse (Murine) Protein Geranylgeranyltransferase Type I, beta Subunit (PGGT1B) interaction partners

  1. The results showed that the magnitude of long-term potentiation (LTP) was markedly suppressed in hippocampal slices from GGT-haplodeficient mice. Consistent with the synaptic dysfunction, there was a significant decrease in cortical spine density and cognitive function in GGT-haplodeficient mice.

  2. This study demonstrated that Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system.

  3. A decrease in membrane-associated Rho proteins in aged brain is associated with down-regulation of GGTase-Ibeta.

  4. Targeting GGTase-I activates RHOA and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation.

  5. deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues

  6. Data show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis.

  7. Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.

Protein Geranylgeranyltransferase Type I, beta Subunit (PGGT1B) Protein Profile

Protein Summary

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994

Gene names and symbols associated with PGGT1B

  • protein geranylgeranyltransferase type I subunit beta (PGGT1B)
  • protein geranylgeranyltransferase type I, beta subunit S homeolog (pggt1b.S)
  • protein geranylgeranyltransferase type 1 subunit beta (Pggt1b)
  • protein geranylgeranyltransferase type I, beta subunit (Pggt1b)
  • 2010207C17Rik protein
  • 2610100E13 protein
  • AI451237 protein
  • AI551093 protein
  • BGG1 protein
  • BGGI protein
  • GGT1 protein
  • GGTI protein
  • MGC115505 protein

Protein level used designations for PGGT1B

protein geranylgeranyltransferase type I, beta subunit , GGTase-I-beta , geranylgeranyl transferase type I subunit beta , geranylgeranyl transferase type-1 subunit beta , geranylgeranyltransferase type I beta subunit , type I protein geranyl-geranyltransferase subunit beta , geranylgeranyltransferase type 1 beta , geranylgeranyltransferase type I (GGTase-I)

GENE ID SPECIES
770633 Gallus gallus
481440 Canis lupus familiaris
734580 Xenopus laevis
5229 Homo sapiens
81746 Rattus norvegicus
225467 Mus musculus
509322 Bos taurus
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