Protein tyrosine Phosphatase, Non-Receptor Type 3 Proteins (PTPN3)

The protein encoded by PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN3 Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPN3 5774 P26045
PTPN3 545622 A2ALK8
Rat PTPN3 PTPN3 362524  
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Top PTPN3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$720.00
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Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$768.00
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PTPN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) interaction partners

  1. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) signaling.

  2. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation

  3. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1.

  4. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma.

  5. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

  6. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced.

  7. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor (show VDR Proteins) expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis.

  8. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma (show MAPK12 Proteins)-binding activity. Ras increases p38gamma (show MAPK12 Proteins) and PTPH1 expression and there is a coupling of increased p38gamma (show MAPK12 Proteins) and PTPH1 protein expression in colon cancer.

  9. regulates TACE (tnf-alpha convertase (show ADAM17 Proteins)}

  10. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) interaction partners

  1. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

  2. PTP-H1 has a role in modulating GHR (show GHR Proteins) signaling and systemic growth through insulin-like growth factor 1 (show IGF1 Proteins) secretion

  3. PTPN3 and PTPN4 are dispensable for TCR signal transduction.

PTPN3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PTPN3

  • protein tyrosine phosphatase, non-receptor type 3 (PTPN3)
  • protein tyrosine phosphatase, non-receptor type 3 (Ptpn3)
  • 9530011I20Rik protein
  • PTP-H1 protein
  • PTPCL protein
  • PTPH1 protein

Protein level used designations for PTPN3

cytoskeletal-associated protein tyrosine phosphatase , protein-tyrosine phosphatase H1 , tyrosine-protein phosphatase non-receptor type 3

GENE ID SPECIES
5774 Homo sapiens
545622 Mus musculus
362524 Rattus norvegicus
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