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RASSF2 encodes a protein that contains a Ras association domain.
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These observations indicate that RASSF2 regulates osteoblast and osteoclast differentiation by inhibiting NF-kappaB (show NFKB1 Antibodies) signalling via association with IkappaB kinase (IKK) alpha (show CHUK Antibodies) and beta forms and suppression of IKK (show CHUK Antibodies) activity.
The K-Ras (show HRAS Antibodies)-specific effector and potential tumor suppressor gene RASSF2 contains a breed-specific expressed tranversion polymorphism as confirmed in day 25 Meishan and white composite swine placentae.
we confirmed that the RASSF2-PAR-4 axis was mainly responsible for miR-7 functions in CAFs using bioinformatics methods. Overexpression of miR-7 in CAFs led to down-regulation of RASSF2, which dramatically decreased the secretion of PAR-4 from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells.
Results suggest that down-regulation of RASSF2, and RASSF6 (show RASSF6 Antibodies) is a tumor-specific phenomenon and their inactivation through CpG island methylation may play important roles in gastric cardia carcinogenesis.
The statistically most significant association rs4813720 correlates with RASSF2 expression and may play a significant role in childhood ALL etiology.
RASSF2 may be an important molecular marker for carcinogenesis, prognosis and progression in gastric cancer
RASSF2 gene is differently methylated in luminal and non-luminal tumors and is a promising suppressor gene with clinical involvement in breast cancer
our results suggest that RASSF2 may function as a tumor suppressor gene
We conclude that EPB41L3 (show EPB41L3 Antibodies), RASSF2 and TSP-1 (show THBS1 Antibodies) genes are involved in the pathogenesis of diffuse gliomas
results suggest that both RASSF1A (show RASSF1 Antibodies) and RASSF2 are novel epigenetically inactivated tumor suppressor genes in Ewing sarcoma and RASSF2 methylation may have prognostic implications for ES patients
our results suggest that RASSF2 potentially functions as a new tumor-suppressor gene that is inactivated through hypermethylation in cervical cancer
Hypermethylation of RASSF2 gene is associated with advanced gastric cancer.
This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.
Ras association (RalGDS/AF-6) domain family 2
, ras association domain-containing protein 2
, Ras association domain family 2
, Ras association (RalGDS/AF-6) domain family member 2
, Ras association (RalGDS/AF-6) domain family 2, like
, Ras association domain-containing protein 2
, ras association domain-containing protein 2-like
, centromere protein 34