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Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. Additionally we are shipping SETDB2 Antibodies (75) and many more products for this protein.
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our data indicated that SETDB2 is often over-expressed in gastric cancer tissues and cell lines and SETDB2 overexpression significantly accelerated cell proliferation, migration and invasion of gastric cancer cells
the relation of genetic variation in SETDB2-and its paralogue SETDB1 (show SETDB1 Proteins)-with different handedness phenotypes in 950 healthy adult participants, was investigated.
Results indicate that the IgE-associated AT/G polymorphism (rs386770867) regulates transcription of SETDB2.
these findings identify Setdb2 as a novel regulator of the immune system in acute respiratory viral infection.
Results provide evidence that CLLD8/KMT1F is recruited to heterochromatin regions and contributes in vivo to the deposition of trimethyl marks in concert with SUV39H1 (show SUV39H1 Proteins)/KMT1A.SUV39H1/KMT1A (show SUV39H1 Proteins).
INSIG2 (show INSIG2 Proteins) is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (show SREBF1 Proteins)-driven lipogenesis.
Results suggest that a Setdb2-mediated regulatory crosstalk between the type I interferons and NF-kappaB (show NFKB1 Proteins) pathways is a mechanism for virus-induced susceptibility to bacterial superinfection.
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003
chronic lymphocytic leukemia deletion region 8
, chronic lymphocytic leukemia deletion region gene 8 protein
, histone-lysine N-methyltransferase SETDB2
, lysine N-methyltransferase 1F
, Setdb2-Phf11-1-Phf11-2 fusion