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SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4.
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Human Polyclonal SETD1A Primary Antibody for ChIP, IHC (p) - ABIN151990
Lee, Tate, You, Skalnik: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. in The Journal of biological chemistry 2007
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Human Polyclonal SETD1A Primary Antibody for ICC, IF - ABIN4353047
Cho, Shimazu, Toyokawa, Daigo, Maehara, Hayami, Ito, Masuda, Ikawa, Field, Tsuchiya, Ohnuma, Ponder, Yoshida, Nakamura, Hamamoto: Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. in Nature communications 2012
SETD1A contributes to retinoic acid -induced thrombomodulin (show THBD Antibodies) expression in vascular endothelial cells by modulating the activity and expression of KLF4 (show KLF4 Antibodies).
Study showed that repressed HBV cccDNA chromatin state is activated by Set1A which mediates its activation by methylating H3K4. Also, Set1A was showed to be recruited to viral promoters in an HBx dependent manner.
Rare loss-of-function variants in SETD1A are associated with Schizophrenia and Developmental disorders. SETD1A is the only gene implicated to date by whole-exome sequencing studies.
data indicate that Setd1a and NURF (show RBBP4 Antibodies) complexes are specifically targeted to and coordinately regulate erythroid promoter chromatin dynamics during erythroid lineage differentiation
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (show CAPS Antibodies) (WDR5 (show WDR5 Antibodies)) and Mixed Lineage Leukemia (MLL (show MLL Antibodies))/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
Study provides evidence that increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates CREMA in systemic lupus erythematosus.
Collectively called the WRAD complex, these proteins are pivotal to the HMT (show HNMT Antibodies) activity of the SET1 complexes. Recent reports highlight the novel non-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation and gene expression.
Given the critical tumor suppressor role of p53 (show TP53 Antibodies), SETD1A-mediated suppression of this pathway (even in the absence of p53 (show TP53 Antibodies) mutations), would be predicted to have profound consequences on tumorigenesis.
Findings provide evidence that SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically.
Loss-of-function variants in SETD1A cause a range of neurodevelopmental disorders in a Finnish population.
a critical role for Set1A catalytic methyltransferase activity in regulating ESC differentiation
SET1A/COMPASS is required for full transcriptional activation of multiple Hox genes but functions independently of the E1 and E2 cis (show CISH Antibodies)-regulatory elements
miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (show DNMT1 Antibodies), DNMT3b (show DNMT3B Antibodies) and SET1A expression in hepatic stellate cells.
our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Antibodies), Sox2 (show SOX2 Antibodies), Klf4 (show KLF4 Antibodies), and Myc (show MYC Antibodies)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Antibodies) and early development
revealed a critical role of Setd1a and its mediated epigenetic modifications in regulating the IgH rearrangement and B-cell development
The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b (show SETD1B Antibodies) becomes essential after gastrulation.
embryonic stem cells lacking Cfp1 (CXXC1 (show CXXC1 Antibodies)(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 (show CXXC1 Antibodies) functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex.
mNSC1 lacks protein-coding capacity
SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005
SET domain containing 1A
, histone-lysine N-methyltransferase SETD1A
, histone-lysine N-methyltransferase SETD1-like protein
, histone-lysine N-methyltransferase SETD1A-like
, SET domain-containing protein 1A
, lysine N-methyltransferase 2F
, set1/Ash2 histone methyltransferase complex subunit SET1
, non-selective cation channel 1