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Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Additionally we are shipping SLITRK6 Antibodies (77) and and many more products for this protein.
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Analysis of two exons of SLITRK6 gene in a Moroccan family identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous state in the exon 2 of the SLITRK6, a gene reported to cause deafness and myopia in various populations.
Human cytomegalovirus downregulates SLITRK6 expression through IE2.
SLITRK6 gene nonsense mutation is associated with progressive auditory neuropathy in humans.
SLITRK6 plays a crucial role in the development of normal hearing as well as vision in humans and in mice and that its disruption leads to a syndrome characterized by severe myopia and deafness.
the altered responses of Slitrk6-KO mice to the novel environment suggest a role of Slitrk6 in some cognitive functions.
Slitrk6 promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia
Slitrk6 gene expression profile in the mouse embryo.
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1\; MIM 603742). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1\; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003
slit and trk like 6
, SLIT and NTRK-like family, member 6
, SLIT and NTRK-like protein 6-like
, SLIT and NTRK-like protein 6
, slit and trk like gene 6
, neuronal transmembrane protein Slitrk6