SLIT-ROBO rho GTPase Activating Protein 2 Proteins (SRGAP2)

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Additionally we are shipping SRGAP2 Antibodies (34) and SRGAP2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SRGAP2 23380 O75044
SRGAP2 14270 Q91Z67
Rat SRGAP2 SRGAP2 360840 D4A208;
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Top SRGAP2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details

SRGAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) Interaction Partners

Human SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. Results show that in high-grade, stage (show SRGAP3 Proteins)II osteosarcoma samples, expression of SRGAP2 was substantially reduced or absent in (show SRGAP3 Proteins)over half of the samples. Functional analysis provides further evidence that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The extended F-BAR (F-BARx) domain of SRGAP2 (show SRGAP3 Proteins) generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 (show SRGAP3 Proteins) was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.

  4. human-specific duplication of SRGAP2 (show SRGAP3 Proteins) might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance

  5. This study illustrated that the role of SRGAP2 (show SRGAP3 Proteins) protein and its human-specific paralogs in human brain development and evolution.

  6. interlocus gene conversions in SRGAP2 (show SRGAP3 Proteins)

  7. SRGAP2 (show SRGAP3 Proteins) has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (show MBL2 Proteins) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.

  8. Results uncover a new function for ancestral SRGAP2 (show SRGAP3 Proteins) in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 (show SRGAP3 Proteins) in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex

  9. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.

  10. srGAP2 (show SRGAP3 Proteins) arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. Results show that the effects of Srgap2 (show SRGAP3 Proteins) expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 (show SRGAP3 Proteins) may have a role as a suppressor of metastases in osteosarcoma.

  2. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.

  3. The inverse F-BAR domain protein srGAP2 (show SRGAP3 Proteins) acts through srGAP3 (show SRGAP3 Proteins) to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (show ARHGEF16 Proteins) cells.

  4. Data show that srGAP2 (show SRGAP3 Proteins) is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.

  5. Study reports that srGAP2 (show SRGAP3 Proteins) negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.

Zebrafish SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2) interaction partners

  1. SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration. Knockdown of SRGAP2a, a SRGAP2 (show SRGAP3 Proteins) ortholog in zebrafish, recapitulates podocyte foot process effacement.

SRGAP2 Protein Profile

Protein Summary

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with SRGAP2

  • SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2)
  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2)
  • SLIT-ROBO Rho GTPase activating protein 2 (srgap2)
  • 9930124L22Rik protein
  • AI448945 protein
  • ARHGAP34 protein
  • FBP2 protein
  • Fnbp2 protein
  • RGD1566016 protein
  • srGAP2 protein
  • srgap2a protein
  • srGAP3 protein
  • wu:fb47h12 protein
  • zgc:136814 protein

Protein level used designations for SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , rho GTPase-activating protein 34 , FBP-27 , formin-binding protein 27 , LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 , SLIT-ROBO Rho GTPase activating protein 2a

GENE ID SPECIES
23380 Homo sapiens
14270 Mus musculus
360840 Rattus norvegicus
100716665 Cavia porcellus
556198 Danio rerio
478949 Canis lupus familiaris
519843 Bos taurus
100050923 Equus caballus
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