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This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Additionally we are shipping SRGAP2 Antibodies (27) and SRGAP2 Kits (2) and many more products for this protein.
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The extended F-BAR (F-BARx) domain of SRGAP2 (show SRGAP3 Proteins) generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 (show SRGAP3 Proteins) was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.
human-specific duplication of SRGAP2 (show SRGAP3 Proteins) might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance
This study illustrated that the role of SRGAP2 (show SRGAP3 Proteins) protein and its human-specific paralogs in human brain development and evolution.
interlocus gene conversions in SRGAP2 (show SRGAP3 Proteins)
SRGAP2 (show SRGAP3 Proteins) has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (show MBL2 Proteins) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.
Results uncover a new function for ancestral SRGAP2 (show SRGAP3 Proteins) in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 (show SRGAP3 Proteins) in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
srGAP2 (show SRGAP3 Proteins) arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.
FNBP2 gene was linked to IKBKE (show IKBKE Proteins) and NORE1 (show RASSF5 Proteins) genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.
The inverse F-BAR domain protein srGAP2 (show SRGAP3 Proteins) acts through srGAP3 (show SRGAP3 Proteins) to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (show ARHGEF16 Proteins) cells.
Data show that srGAP2 (show SRGAP3 Proteins) is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Study reports that srGAP2 (show SRGAP3 Proteins) negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
SLIT-ROBO Rho GTPase-activating protein 2
, formin binding protein 2
, formin-binding protein 2
, rho GTPase-activating protein 34
, formin-binding protein 27
, LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2
, SLIT-ROBO Rho GTPase activating protein 2a