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The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT\; EC 220.127.116.11), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]).
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The association between the SPTLC3 rs364585 SNP and serum total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels in the Han and Jing populations
Data identified LC3B (show MAP1LC3B Antibodies) globular structures in esophageal adenocarcinoma patients strongly associated with patient outcome irrespective of treatment.
Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1 (show SPTLC1 Antibodies), SPTLC2 (show SPTLC2 Antibodies) and SPTLC3) with a molecular mass of 480 kDa.
Data show that the SPTLC3 subunit generates C(16)-sphingoid bases and that sphingolipids with a C(16) backbone constitute a significant proportion of plasma sphingolipids.
hepatic expression of Sptlc3 mRNA may be closely associated with NASH (show SAMSN1 Antibodies)-associated hepatocarcinogenesis.
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT\; EC 18.104.22.168), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006
serine palmitoyltransferase, long chain base subunit 3
, serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)
, serine palmitoyltransferase 3-like
, serine palmitoyltransferase 3
, LCB 3
, SPT 3
, long chain base biosynthesis protein 2b
, long chain base biosynthesis protein 3
, serine-palmitoyl-CoA transferase 3