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Involved in pre-mRNA splicing.
Showing 5 out of 5 products:
cellular complexes comprising cactin (show CACTIN Antibodies), DHX8 (show DHX8 Antibodies) and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs.
The S346F mutation in SRRM2 predisposes to papillary thyroid carcinoma by affecting alternative splicing of unidentified downstream target genes.
Data show that the consistent dysregulation of the RNA splicing factor (show SLU7 Antibodies) SRRM2 in two different PD neuronal sources and in PD blood makes SRRM2 a strong candidate gene for PD and draws attention to the role of RNA splicing in the disease.
results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1 (show ISY1 Antibodies).
demonstrate that SRm300, the only serine arginine-related protein known to be at the core of human catalytic spliceosomes, is a functional ortholog of Cwc21p, also interacting directly with Prp8p and Snu114p.
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA (By similarity).
300 kDa nuclear matrix antigen
, RNA binding protein
, SR-related nuclear matrix protein of 300 kDa
, ser/Arg-related nuclear matrix protein of 300 kDa
, serine/arginine repetitive matrix protein 2
, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
, splicing coactivator subunit SRm300
, tax-responsive enhancer element-binding protein 803