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SPPL2B Proteins

(Signal Peptide Peptidase-Like 2B (SPPL2B))
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Popular SPPL2B Proteins

Aliases for SPPL2B Proteins

signal peptide peptidase-like 2 (sppl2) Proteins
signal peptide peptidase like 2B (sppl2b) Proteins
signal peptide peptidase like 2B S homeolog (sppl2b.S) Proteins
signal peptide peptidase like 2B (SPPL2B) Proteins
signal peptide peptidase like 2B (Sppl2b) Proteins
signal peptide peptidase-like 2B (Sppl2b) Proteins
3110056O03Rik Proteins
AW550292 Proteins
IMP-4 Proteins
IMP4 Proteins
MGC147524 Proteins
PSH4 Proteins
PSL1 Proteins
RGD1308556 Proteins
SPPL2B Proteins
wu:fc16e01 Proteins
wu:fc85d12 Proteins
zgc:136525 Proteins
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