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SPPL2B encodes a member of the GXGD family of aspartic proteases.
Showing 4 out of 5 products:
SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.
TfR1 (show TFRC Proteins) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.
The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (show ITM2B Proteins)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).
SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis
Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (show TNF Proteins) into the cytosol.
SPPL2a (show SPPL2A Proteins) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B Proteins) N-terminal fragment.
Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (show TNF Proteins) and caused a relative increase of longer intracellular cleavage products.
in vivo SPPL2a (show SPPL2A Proteins), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (show CD74 Proteins) proteolysis in B and dendritic cells
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.
signal peptide peptidase-like 2B
, signal peptide peptidase-like protein 2
, SPP-like 2B
, protein SPP-like 2B
, protein SPPL2b
, intramembrane protease 4
, presenilin homologous protein 4
, presenilin-like protein 1