Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins (SLC22A8)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies (53) and Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A8 9376 Q8TCC7
SLC22A8 19879 O88909
Rat SLC22A8 SLC22A8 83500 Q9R1U7
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Top Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

SLC22A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaction Partners

Human Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

  2. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (show KCNK3 Proteins)/OAT3.

  3. The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Proteins)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.

  4. PPIs inhibit [(3)H]MTX (show MTX1 Proteins) transport via hOAT3 inhibition.

  5. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.

  6. Pemetrexed is a superior substrate to methotrexate for hOAT3.

  7. In HEK293-Flp (show HPD Proteins)-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

  8. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.

  9. transport of xanthurenic acid by OAT1 (show KCNK3 Proteins) and OAT3

  10. Both hOAT1 (show SLC22A6 Proteins) and hOAT3 markedly stimulated the uptake of kynurenic acid into oocytes.

Mouse (Murine) Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. OAT1 (show SLC22A6 Proteins) plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney

  2. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Proteins) and OAT3).

  3. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  4. Oat3 also plays a role in bioenergetic pathways.

  5. At the protein level, mOat3 and mOat1 (show SLC22A6 Proteins) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Proteins) is male dominant due to androgen stimulation.

  6. The results are consistent with a contribution of OAT3 and possibly OAT1 (show SLC22A6 Proteins) to renal creatinine secretion in mice.

  7. DAT (show SLC6A3 Proteins) and Oct3 (show POU5F1 Proteins) modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling

  8. functional differences in the relative importance of OAT1 (show SLC22A6 Proteins) and OAT3 in antiviral handling in developing and mature tissue

  9. the ontogenic pattern of expression of OAT1 (show SLC22A6 Proteins) and OAT3 in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  10. Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter)

Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Protein Profile

Protein Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with SLC22A8

  • solute carrier family 22 member 8 (SLC22A8)
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8)
  • solute carrier family 22 member 8 (Slc22a8)
  • Oat3 protein
  • OCT3 protein
  • Roct protein

Protein level used designations for SLC22A8

hOAT3 , organic anion transporter 3 , solute carrier family 22 member 8 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3 , pOAT3

GENE ID SPECIES
9376 Homo sapiens
19879 Mus musculus
83500 Rattus norvegicus
404128 Bos taurus
100008845 Oryctolagus cuniculus
451274 Pan troglodytes
100172896 Pongo abelii
476049 Canis lupus familiaris
407774 Sus scrofa
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