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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies (59) and Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (2) and many more products for this protein.
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Sgk1 (show SGK1 Proteins) stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 (show NEDD4L Proteins) on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo.
SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (show KCNK3 Proteins)/OAT3.
The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Proteins)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
PPIs inhibit [(3)H]MTX (show MTX1 Proteins) transport via hOAT3 inhibition.
The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
Pemetrexed is a superior substrate to methotrexate for hOAT3.
In HEK293-Flp (show HPD Proteins)-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].
The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.
transport of xanthurenic acid by OAT1 (show KCNK3 Proteins) and OAT3
vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 (show CYP7A1 Proteins) and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.
OCT2 (show SLC22A2 Proteins)-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 (show SLC22A6 Proteins) and OAT3, is reported.
OAT1 (show SLC22A6 Proteins) plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Proteins) and OAT3).
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
At the protein level, mOat3 and mOat1 (show SLC22A6 Proteins) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Proteins) is male dominant due to androgen stimulation.
The results are consistent with a contribution of OAT3 and possibly OAT1 (show SLC22A6 Proteins) to renal creatinine secretion in mice.
DAT (show SLC6A3 Proteins) and Oct3 (show POU5F1 Proteins) modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling
functional differences in the relative importance of OAT1 (show SLC22A6 Proteins) and OAT3 in antiviral handling in developing and mature tissue
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
, organic anion transporter 3
, solute carrier family 22 member 8
, reduced in osteosclerosis transporter
, solute carrier family 22, member 8
, solute carrier family 22 ,member 8
, renal organic anion transporter 3