Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins (SLC22A8)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies (82) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A8 9376 Q8TCC7
SLC22A8 19879 O88909
Rat SLC22A8 SLC22A8 83500 Q9R1U7
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Top Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

SLC22A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaction Partners

Human Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. Endogenous metabolite-mediated communication between OAT1/OAT3 and OATP1B1 may explain the association between SLCO1B1 SNPs and methotrexate toxicity.

  2. Sgk1 stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo.

  3. is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs.

  4. SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

  5. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1/OAT3.

  6. The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.

  7. high capacity p-cresyl sulfate trasnporter

  8. PPIs inhibit [(3)H]MTX transport via hOAT3 inhibition.

  9. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.

  10. Pemetrexed is a superior substrate to methotrexate for hOAT3.

  11. In HEK293-Flp-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

  12. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.

  13. transport of xanthurenic acid by OAT1 and OAT3

  14. Both hOAT1 and hOAT3 markedly stimulated the uptake of kynurenic acid into oocytes.

  15. High urine OAT1, OAT3 and OAT4 is associated with severe acute kidney injury.

  16. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3

  17. Intergenic polymorphism rs10792367 between OAT1 and OAT3 is not associated with hypertension, but appears to be involved in between-individual variations in antihypertensive responses to hydrochlorothiazide.

  18. Interaction of human OAT3 with 2,3-dimercapto-1-propanesulfonic acid (DMPS) determines the effect of human OAT3 on basolateral DMPS uptake in rabbit renal proximal tubules.

  19. Angiotensin II inhibited hOAT3 activity through the activation of PKCalpha, which led to an acceleration of hOAT3 endocytosis.

  20. elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs

Mouse (Murine) Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. OAT3 increases the glucosuric effect of empagliflozin, which may relate to the partial overlap of its localization with SGLT2 and thus OAT3-mediated tubular secretion of empagliflozin in the early proximal tubule.

  2. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.

  3. OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.

  4. OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney

  5. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).

  6. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  7. Oat3 also plays a role in bioenergetic pathways.

  8. At the protein level, mOat3 and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.

  9. The results are consistent with a contribution of OAT3 and possibly OAT1 to renal creatinine secretion in mice.

  10. DAT and Oct3 modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling

  11. functional differences in the relative importance of OAT1 and OAT3 in antiviral handling in developing and mature tissue

  12. the ontogenic pattern of expression of OAT1 and OAT3 in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  13. Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter)

  14. For PAH, FL, and estrone sulfate, all Oat3-mediated transport was Na dependent in choroid plexus

  15. Results indicate that mOAT3 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.

  16. These results indicate that the tissue-specific expression of hOAT3 might be regulated by the concerted effect of genetic (HNF1alpha and HNF1beta) and epigenetic (DNA methylation) factors.

  17. mOat3 plays an important role as a basolateral transport pathway of PGE(2) in the distal nephron.

  18. urinary excretion of topotecan hydroxyl acid is accounted for by transport via OAT3, as well as glomerular filtration, in both rats and humans

  19. Functional Oat3 is necessary for proper elimination of xenobiotic and endogenous compounds in vivo.

  20. despite sharing close overall sequence homology, Oat1, Oat3, and Oat6 have signficantly different binding pockets

Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Protein Profile

Protein Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with SLC22A8

  • solute carrier family 22 member 8 (SLC22A8)
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8)
  • solute carrier family 22 member 8 (Slc22a8)
  • Oat3 protein
  • OCT3 protein
  • Roct protein

Protein level used designations for SLC22A8

hOAT3 , organic anion transporter 3 , solute carrier family 22 member 8 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3 , pOAT3

9376 Homo sapiens
19879 Mus musculus
83500 Rattus norvegicus
404128 Bos taurus
100008845 Oryctolagus cuniculus
451274 Pan troglodytes
100172896 Pongo abelii
476049 Canis lupus familiaris
407774 Sus scrofa
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