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Slc24a4 encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Additionally we are shipping Solute Carrier Family 24 (Sodium/potassium/calcium Exchanger), Member 4 Antibodies (19) and many more products for this protein.
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no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE (show APOE Proteins)) epsilon4 carriers nor non-carriers after adjusting for age and gender
pigment cells express robust, functional NCKX4 activity
mutations in SLC24A4 and SLC24A5 (show SLC24A5 Proteins) are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients.
The expressions of NCX1 (show SLC8A1 Proteins) and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels.
enamel maturation is dependent upon STIM1 (show STIM1 Proteins) and SLC24A4 function, and that there are important differences in the Ca(2 (show CA2 Proteins)+) transcellular transport systems used by secretory- and maturation-stage ameloblasts.
Brain DNA methylation (show HELLS Proteins) in sLC24A4 was associated with pathological Alzheimer disease.
These findings support a key role for SLC24A4 in calcium transport during enamel formation.
Taken together, these data demonstrate a potentially important role for NCX1 (show SLC8A1 Proteins) in control of Ca2 (show CA2 Proteins)+ homeostasis and link store depletion via STIM1 (show STIM1 Proteins) directly with NCX (show TLX2 Proteins) activation.
IRF4 (show IRF4 Proteins) and SLC24A4 loci are associated with human hair color and skin pigmentation.
immunostaining of the apical plasma membranes of fluorotic ameloblasts was strongly reduced or absent suggesting that trafficking of NCKX4 to the apical membrane was strongly reduced
olfactory sensory neurons in NCKX4(-/-);CNGB1 (show CNGB1 Proteins)(DeltaCaM) mice displayed markedly reduced electro-olfactogram amplitude accompanied by alterations in other response attributes
These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2 (show CA2 Proteins)+) signaling in the MC4R (show MC4R Proteins) pathway that leads to satiety, and a novel non-redundant role for NCKX4-mediated Ca(2 (show CA2 Proteins)+) extrusion in controlling MC4R (show MC4R Proteins) signaling
NCKX4 activity is stimulated by ATP through activation of the P2Y (show P2RY1 Proteins) receptor signalling pathway.
NCKX4 might be an important regulator of Ca(2 (show CA2 Proteins)+) transport during amelogenesis.
These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception.
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
, solute carrier family 24 member 4-like
, Na(+)/K(+)/Ca(2+)-exchange protein 4
, sodium/potassium/calcium exchanger 4
, K-dependent Na/Ca exchanger NCKX4