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SLCO1C1 encodes a member of the organic anion transporter family. Additionally we are shipping SLCO1C1 Antibodies (14) and many more products for this protein.
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The genetic variant, rs3794271, located within the PDE3A (show PDE3A Proteins)-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF (show TNF Proteins) response in a large UK rheumatoid arthritis cohort.
We found a highly significant association between PDE3A (show PDE3A Proteins)-SLCO1C1 and the clinical response to TNF (show TNF Proteins) blockers
The PDE3A (show PDE3A Proteins)-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF (show TNF Proteins) treatment response.
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.
We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis.
OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy.
OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation
OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.
This study identified the thyroid hormone (show PTH Proteins) transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex
The data demonstrate that OATP1c1 and MCT8 (show MCT8 Proteins) expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
Transporters MCT8 (show MCT8 Proteins) and OATP1C1 maintain murine brain thyroid hormone (show PTH Proteins) homeostasis.
SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.
expression of candidate thyroid hormone (show PTH Proteins) transporters Lat1, Mct8 (show MCT8 Proteins), Mct10, and Oatp1c1 in mouse cochlear development
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.
, organic anion transporter F
, organic anion transporter polypeptide-related protein 5
, organic anion transporting polypeptide 14
, organic anion-transporting polypeptide 14
, solute carrier family 21 (organic anion transporter), member 14
, solute carrier family 21 member 14
, solute carrier organic anion transporter family member 1C1
, thyroxine transporter
, organic anion transporter 2
, BBB-specific anion transporter type 1
, blood-brain barrier specific anion transporter
, blood-brain barrier-specific anion transporter 1