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SNX10 encodes a member of the sorting nexin family. Additionally we are shipping SNX10 Antibodies (30) and many more products for this protein.
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In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (show CSF1 Proteins) (MIOP) and identified mutations in four MIOP-related genes (CLCN7 (show CLCN7 Proteins), TCIRG1 (show TCIRG1 Proteins), SNX10, and TNFRSF11A (show TNFRSF11A Proteins)).
supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis (show CSF1 Proteins)
Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis (show CSF1 Proteins) patients) affects protein-protein interactions of SNX10.
results confirm the involvement of the SNX10 gene in human ARO (show CYP19A1 Proteins) and identify a new subset with a relatively favorable prognosis as compared to TCIRG1 (show TCIRG1 Proteins)-dependent cases
Structure of sorting nexin 11 (SNX11 (show SNX11 Proteins)) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.
Identification of SNX10 as a new osteopetrosis (show CSF1 Proteins) associated gene in consanguineous families of Palestinian origin.
SNX10 regulates the ciliary trafficking of Rab8a (show RAB8A Proteins), which is a critical regulator of ciliary membrane extension.
SNX10 activity may be involved in the regulation of endosome homeostasis
results first identified the role of SNX10 in MMP9 (show MMP9 Proteins) trafficking and secretion, and provided an evidence for SNX10 as a possible therapeutic target for bone destructing disease.
SNX10 plays an important role in the bone destruction of collagen-induced arthritis mice.
data disclose a crucial role and novel function for SNX10 in macrophage polarization. Loss of SNX10 function may be a potential promising therapeutic strategy for IBD.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.
sorting nexin 10
, sorting nexin-10