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SNX4 encodes a member of the sorting nexin family. Additionally we are shipping Sorting Nexin 4 Antibodies (78) and and many more products for this protein.
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Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1 (show BACE Proteins), as well as the subsequent increase in BACE1 (show BACE Proteins)-mediated cleavage, may be relevant to Alzheimer's disease progression.
alpha-taxilin interacts with SNX4 and plays a role in the recycling pathway of TfnR.
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Sorting nexin 4 and amphiphysin 2 (show BIN1 Proteins) have roles in endocytosis and intracellular trafficking
study indicates that hVps34 (show PIK3C3 Proteins) and its product PI(3 (show PI3 Proteins))P are involved in endosome to Golgi transport of ricin, and that SNX2 (show SNX2 Proteins) and SNX4 are likely to be effectors in this pathway
by driving membrane tubulation, SNX4 coordinates iterative, geometric-based sorting of the TfnR with the long-range transport of carriers from early endosomes to the ERC (show ERC1 Proteins)
clathrin serving as a regulator of SNX4-dependent transport; upon clathrin release, dynein may bind SNX4 and mediate retrograde movement
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
, sorting nexin 4
, sorting nexin-4-like
, potential endosome sorting nexin Snx4p