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SP3 belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. Additionally we are shipping Sp3 Transcription Factor Kits (1) and and many more products for this protein.
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Sp1 (show PSG1 Antibodies), Sp3 and Sp4 (show SP4 Antibodies) are non-oncogene (show RAB1A Antibodies) addiction (NOA (show DLAT Antibodies)) genes and are attractive drug targets for individual and combined cancer chemotherapies.
High SP3 expression is associated with hepatocellular carcinoma.
we established a new regulatory model of COL1A1 (show COL1A1 Antibodies) regulation by HIF-1 (show HIF1A Antibodies), and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 (show COL1A1 Antibodies) gene expression.
Data indicate that the antitumor activity of trefoil factor 2 (TFF2 (show TFF2 Antibodies)) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 (show OLFM4 Antibodies) binding is essential to the basal expression of KLF5 (show KLF5 Antibodies)
Sp1 (show PSG1 Antibodies) and Sp3 are not only essential for the basal transcription of the ek1 (show EPHA3 Antibodies) gene, their accessibility to the target site on the ek1 (show EPHA3 Antibodies) promoter is regulated by histone protein modification in a cell line dependent manner.
Human SP1 and SP3 transcription factors regulate MALAT1 expression in hepatocellular carcinoma.
result indicated that promoter binding by Sp1 (show PSG1 Antibodies)/Sp3 was essential, but not a limiting step, for hTERT transcription
Sp3 was found to be a major regulator of BNIP3 (show BNIP3 Antibodies) in prostate cancer.
stimulates CCR7 (show CCR7 Antibodies) expression during the course of dendritic cell maturation
This resulted in Sp1 (show SP1 Antibodies) displacement from the promoter and binding of Sp3 to it, leading to p300 (show NOTCH1 Antibodies) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (show TLR5 Antibodies) expression in the intestine. Additionally, a novel insight is gained into Sp1 (show SP1 Antibodies)/Sp3-mediated gene regulation that may apply to other genes
Sp3 binds and activates the FGFR4 (show FGFR4 Antibodies) promoter.
Dp71 (show DMD Antibodies) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Antibodies)-, Sp1 (show SP1 Antibodies)- and Sp3-mediated transcription from the Dp71 (show DMD Antibodies) promoter.
Our results unveil strikingly different recruitment mechanisms of Sp1 (show SP1 Antibodies)/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
Sp1 (show SP1 Antibodies)/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Sp1 (show SP1 Antibodies)/3 transcription factors trigger Mina (show MINA Antibodies) expression through additive activity targeted to a cluster of four Sp1 (show SP1 Antibodies)/3 binding sites forming the P1 promoter.
an interplay between Sp1 (show SP1 Antibodies) and Sp3 as a mechanism involved in the control of Fiat (show TXLNG Antibodies) gene expression in osteoblasts.
Oct-6 (show POU3F1 Antibodies) and Oct-11 (show POU2F3 Antibodies) contribute to the regulation of loricrin (show LOR Antibodies) gene transcription via interaction with AP-1 (show JUN Antibodies) factors and Sp1 (show SP1 Antibodies)/Sp3.
inhibition of FGF-10 (show FGF10 Antibodies) by inflammatory signaling involves the NF-kappaB (show NFKB1 Antibodies)-dependent interactions between RELA (show NFkBP65 Antibodies), SP3, and the Fgf-10 (show FGF10 Antibodies) promoter.
Three GC boxes within the proximal promoter of the murine pyruvate carboxylase (show PC Antibodies) gene bind Sp1 (show SP1 Antibodies)/Sp3
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
Sp3 transcription factor
, sp3 transcription factor
, transcription factor Sp3
, specificity protein 3
, GC-binding transcription factor Sp3