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Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Additionally we are shipping Sulfatase 2 Kits (24) and Sulfatase 2 Proteins (7) and many more products for this protein.
Showing 10 out of 104 products:
Human Monoclonal SULF2 Primary Antibody for CyTOF, ELISA - ABIN450044
Lemjabbar-Alaoui, van Zante, Singer, Xue, Wang, Tsay, He, Jablons, Rosen: Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. in Oncogene 2010
Show all 6 Pubmed References
Cow (Bovine) Polyclonal SULF2 Primary Antibody for IHC, WB - ABIN2783715
Uchimura, Morimoto-Tomita, Bistrup, Li, Lyon, Gallagher, Werb, Rosen: HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. in BMC biochemistry 2006
Human Polyclonal SULF2 Primary Antibody for ELISA, WB - ABIN4356740
Dai, Yang, MacLeod, Yue, Rapraeger, Shriver, Venkataraman, Sasisekharan, Sanderson: HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. in The Journal of biological chemistry 2005
Sulf2 expression is almost entirely restricted to the CNS.
SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways.
Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva (show RAG1AP1 Antibodies) makes it worthy of further investigation as a potential HNSCC biomarker.
results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo
The short variants of Sulf2 promoted FGF2 (show FGF2 Antibodies)-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 (show SULF1 Antibodies) inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth.
Most pancreatic ductal adenocarcinomas had positive SULF2 staining in tumour cells and intratumoural or tumour-adjacent stroma. Elevated SULF2 in PDAC was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival.
The SULF1/SULF2 (show SULF1 Antibodies) activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth.
Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D (show Figf Antibodies) and that the AKT1related signaling pathway was involved.
renal cell carcinoma (show MOK Antibodies) with lower SULF-2 expression might have a higher potential for cell invasion and proliferation, leading to a poorer prognosis via the activation of VEGF (show VEGFA Antibodies) and/or FGF signaling
SULF2 is a multifaceted protein involved in triglyceride-rich lipoprotein homeostasis and angiogenesis. [review]
Our data confirmed that Sulf2 promoted breast cancer progression and regulated the expression of tumor-related genes in breast cancer.
Shh (show SHH Antibodies) signaling requires the coordinated activity of Sulf1 (show SULF1 Antibodies) and Sulf2 in order to reach that threshold in the mouse ventral spinal cord
Sulf1 (show SULF1 Antibodies) and Sulf2 play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 (show SULF1 Antibodies) and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
It is proposed that Sulf1 (show SULF1 Antibodies), Sulf2 and ErbB1 (show EGFR Antibodies) are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
Sulf1 (show SULF1 Antibodies)/, but not Sulf2/, mice, exhibited a marked delay in healing of corneal epithelial wounds.
SULF2 regulates tissue regeneration in part via the activation of a novel WNT (show WNT2 Antibodies)-GLI1 (show GLI1 Antibodies)-CYCLIN D1 (show CCND1 Antibodies) pathway.
Sulf1 (show SULF1 Antibodies) and Sulf2 differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.
Heparan sulfate sulfatase (show SGSH Antibodies) SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma
Sulf-1 (show SULF1 Antibodies) and Sulf-2 are essential regulators of GDNF signaling in the SSC (show CYP11A1 Antibodies) niche and direct downstream targets of Sertoli cell-specific transcriptional factor Wilm's tumor 1.
SULF2 is an unexpected suppressor of atherogenic lipoprotein clearance by hepatocytes
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005
, extracellular sulfatase Sulf-2-like
, extracellular sulfatase Sulf-2
, sulfatase FP2a
, sulfatase FP2b
, sulfatase FP2