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The protein encoded by SQRDL may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Additionally we are shipping SQRDL Kits (4) and SQRDL Proteins (2) and many more products for this protein.
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The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.
Levels of mRNA encoding SQR were higher in the colonic muscularis externa and the liver than in the brain.
The evidence supported the significant role of SQRDL in the etiology of postmenopausal osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women.
Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase
Therefore, this study reveals the reduction in SQR activity as one of the pathomechanisms associated with Coenzyme Q deficiency syndrome.
Data, including data from studies using recombinant SQR immobilized by embedding in nanodiscs, suggest that immobilized SQR exhibits enhanced catalytic performance; pre-steady-state kinetic characterization of immobilized SQR catalytic cycle indicates that glutathione serves as physiologically relevant sulfur acceptor during hydrogen sulfide oxidation.
The I264T SQRDL polymorphism is associaated with osteoporosis in Korean postmenopausal women.
SQR is part of the human mitochondrial hydrogen sulfide oxidation pathway
Sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.
The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein.
, sulfide:quinone oxidoreductase, mitochondrial
, sulfide dehydrogenase like
, sulfide quinone reductase-like
, LOW QUALITY PROTEIN: sulfide:quinone oxidoreductase, mitochondrial
, sulfide:quinone oxidoreductase mitochondrial-like protein