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BTAF1 encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II.
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Results support a model for a BTAF1-mediated release of TBP (show TBP Antibodies)-NC2 (show GTF2H5 Antibodies) complexes from chromatin.
study with the first structural model of the B-TFIID complex and map of its key functional domains
physical cooperation between BTAF1 and NC2alpha in TBP (show TBP Antibodies) regulation
We propose that these density rearrangements in the structure are a likely reflection of the plasticity of the interactions between TFIID and its many partner proteins.
histone acetylation, although it occurs, is dispensable for TFIID (show TBP Antibodies) and SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) recruitment by the strong enhancers
This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters.
ATP-dependent helicase BTAF1
, B-TFIID transcription factor-associated 170 kDa subunit
, BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
, Mot1 homolog
, TATA-binding protein-associated factor 172
, TBP-associated factor 172