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The protein encoded by TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. Additionally we are shipping TGIF2 Proteins (6) and many more products for this protein.
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Human Polyclonal TGIF2 Primary Antibody for ELISA, WB - ABIN269815
Melhuish, Gallo, Wotton: TGIF2 interacts with histone deacetylase 1 and represses transcription. in The Journal of biological chemistry 2001
Human Polyclonal TGIF2 Primary Antibody for WB - ABIN528411
Hu, Yu, Shaw, Renfree, Pask: Differential roles of TGIF family genes in mammalian reproduction. in BMC developmental biology 2011
Tgifs regulate ciliogenesis and suggests that Evi5l (show EVI5L Antibodies) mediates at least part of this effect.
Authors suggest that miR (show MLXIP Antibodies)-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR (show MLXIP Antibodies)-148a/TGFI2 axis in the malignant progression of OC.
Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR (show MLXIP Antibodies)-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells.
expression of miR (show MLXIP Antibodies)-148a was regulated by DNA methylation (show HELLS Antibodies) and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer
miR (show MLXIP Antibodies)-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2
Corneal fibroblasts demonstrate the expression of TGIF1 (show TGIF1 Antibodies) and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea.
Shows that the homologous mouse Tgif2 gene is necessary (show TGIF1 Antibodies) for gastrulation.
loss of Tgif1 (show TGIF1 Antibodies) causes axial patterning defects that are enhanced by mutations in Tgif2
Data show that loss-of-function mutations in both Tgif1 (show TGIF1 Antibodies) and Tgif2 result in a failure of gastrulation.
TGIF2 has a wide but well controlled expression pattern during mouse development.
The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region.
TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
TGFB-induced factor homeobox 2
, 5'-TG-3' interacting factor 2
, TGF(beta)-induced transcription factor 2
, TGF-beta-induced transcription factor 2
, TGFB-induced factor 2 (TALE family homeobox)
, homeobox protein TGIF2
, transcription growth factor-beta-induced factor 2
, 5'-TG-3'-interacting factor 2
, TALE family homeobox
, TGFB-induced factor 2