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TAS2R50 belongs to the large TAS2R receptor family.
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genetic association studies in populations in Northern Europe, Maghreb, and Sri (show SRI Antibodies) Lanka: Data suggest that SNPs in TAS2R50 (rs1376251), TRPM5 (show TRPM5 Antibodies) (rs800345), and TAS2R16 (show TAS2R16 Antibodies) (rs860170) are associated with cultural food preferences; TAS2R16 (show TAS2R16 Antibodies) (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TRPM5 (show TRPM5 Antibodies) = transient receptor potential cation channel subfamily M member 5 (show TRPM5 Antibodies))
Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
TAS2R50 is activated by the natural bitter terpenoids andrographolide and amarogentin.
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002
taste receptor type 2 member 50
, taste receptor T2R50
, taste receptor type 2 member 51