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The protein encoded by TSPAN8 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 8 Antibodies (99) and Tetraspanin 8 Proteins (7) and many more products for this protein.
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overexpression of tm4sf3 promoted development of annular pancreas.
LCMR1 (show MED19 ELISA Kits) modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo.
Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK (show ILK ELISA Kits)) axis and establish Tspan8 as a negative regulator of ILK (show ILK ELISA Kits) activity.
TSPAN8 might be important for the orchestration of meprin beta (show MEP1B ELISA Kits) at the cell surface with impact on certain proteolytic processes
Knocking down TSPAN8 in AEG-1 (show MTDH ELISA Kits)-overexpressing human hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1 (show MTDH ELISA Kits)-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice
Knockdown and knockout models revealed that CD151 (show CD151 ELISA Kits) and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review]
Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation.
TSPAN8 is involved in tumor progression and is an independent prognostic classifier in patients with gastric cancer.
This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR (show AR ELISA Kits)) in both androgen-dependent and androgen-independent prostate cancer cell lines
Our data suggest that TSPAN8-LEL may play an important role in mCRC cell invasion, and that the antibody we have developed could be a useful tool for inhibiting the invasion of TSPAN8-expressing mCRCs.
Based on nasopharyngeal TSPAN8 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
Transplantation studies provided definitive evidence that a TSPAN8-high subpopulation is enriched for spermatogonial stem cells.
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
, transmembrane 4 superfamily member 3
, tumor-associated antigen CO-029