Torsin Family 1, Member A (Torsin A) Proteins (TOR1A)

The protein encoded by TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Additionally we are shipping Torsin Family 1, Member A (Torsin A) Antibodies (74) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TOR1A TOR1A 266606  
TOR1A 1861 O14656
TOR1A 30931 Q9ER39
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Top Torsin Family 1, Member A (Torsin A) Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
$400.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cricetus cricetus His tag   1 mg Log in to see 60 to 71 Days
$2,713.33
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$736.00
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TOR1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for Torsin Family 1, Member A (Torsin A) (TOR1A) Interaction Partners

Human Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. Association between rs35153737 TOR1A variant and dystonia in a southwestern Chinese population.

  2. TOR1A exon 5 c.*302T>A is associated with isolated dystonia in southwestern Chinese.

  3. TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models

  4. This study does not allow the establishment of genotype-specific clinical correlations for DYT1 in patient with isolated dystonia.

  5. This study show both MDYT1 and without clinical symptoms showed an abnormally enhanced Abnormal blink (show TGFb Proteins) reflex recovery curve compared with the healthy controls. Moreover, the lack of a statistical difference between manifesting and nonmanifesting carriers suggests that their brainstem circuits are equivalently affected by the DYT1. gene

  6. A comparison of these structures shows, in atomic detail, the subtle differences in TorsinADeltaE-LULL1 (show TOR1AIP2 Proteins) activator interactions that separate the healthy from the diseased state.

  7. found that human Torsin1A and human FMRP (show FMR1 Proteins) were present in the same protein complexes, suggesting that this phenomenon is evolutionarily conserved

  8. The significant association of rs1182 and rs1801968 TOR1A variants was found in the development of focal dystonia and writer's cramp respectively.

  9. This study demonstrated that whole-exome sequencing show reveled TOR1A mutation with early-onset generalized dystonia.

  10. This study showed that the Phosphodiesterase-10A (show PDE10A Proteins) Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.

Mouse (Murine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. Results show that direct pathological insult to forebrain torsinA in a symptomatic mouse model of DYT1 dystonia can engage genetically normal hindbrain regions into an aberrant connectivity network. These findings have important implications for the assignment of a causative region in CNS disease.

  2. that the deletion of a 3-base pair (DeltaGAG) sequence in the Dyt1 gene encoding torsinA has network level effects on in vivo functional connectivity and microstructural integrity across the sensorimotor cortex, basal ganglia, and cerebellum

  3. TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models

  4. Abnormal motor symptoms in DYT1 knockdown animals were associated with irregular cerebellar output caused by changes in the intrinsic activity of both Purkinje cells and neurons of the deep cerebellar nuclei.

  5. Study linked the genetic defect of reduced torsinA expression in a DYT1 related mouse model to a maladaptive response of the striatal dopaminergic system after a peripheral nerve lesion and to the manifestation of dystonia-like movements

  6. The nuclear envelope-localized AAA (show AAAS Proteins)+ (ATPase associated with various cellular activities) torsinA (TA) and its activator, the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1 (show TRAF3 Proteins)), are required for rearward nuclear movement.

  7. Authors find no effect of this anatomic-specific expression of the DYT1 genotype.

  8. The data suggest that LULL1 (show TOR1AIP2 Proteins) oligomerizes to engage and transiently disassemble torsinA oligomers, and is thereby positioned to transduce cytoplasmic signals to the inner nuclear membrane through torsinA.

  9. These findings demonstrate that dorsal dorsal striatal large cholinergic interneurons have a unique requirement for torsinA function during striatal maturation, and link abnormalities of these cells to dystonic-like movements.

  10. maintaining an appropriate torsinA level is important to sustain normal motor performance, synaptic transmission and plasticity

Pig (Porcine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. This work reports the cloning and analysis of the porcine (Sus scrofa) homologue of TOR1A.

Torsin Family 1, Member A (Torsin A) (TOR1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.

Gene names and symbols associated with TOR1A

  • torsin family 1, member A (Tor1a)
  • torsin family 1 member A (TOR1A)
  • torsin family 1, member A (torsin A) (Tor1a)
  • DQ2 protein
  • DYT1 protein
  • torsinA protein

Protein level used designations for TOR1A

dystonia 1, torsion (autosomal dominant , dystonia 1, torsion (autosomal dominant; torsin A) , torsin A , torsin-1A , dystonia 1 protein , torsin family 1 member A

GENE ID SPECIES
266606 Rattus norvegicus
1861 Homo sapiens
30931 Mus musculus
100125953 Sus scrofa
533699 Bos taurus
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