Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Proteins (TRPC6)

The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antibodies (135) and Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPC6 7225 Q9Y210
TRPC6 22068 Q61143
Rat TRPC6 TRPC6 89823  
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Top Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,639.51
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg Log in to see 15 to 18 Days
$717.00
Details

TRPC6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine) ,
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More Proteins for Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. axonal colocalization of TRPV4 (show TRPV4 Proteins) and TRPC6 was found in the digital Meissner corpuscles

  2. Data suggest that TRPC6-mediated elevation of intracellular Ca2 (show CA2 Proteins)+ stimulates non-small cell lung cancer proliferation by promoting cell cycle progression.

  3. potential implications of transient receptor potential (TRP) channels in the pathogenesis of intestinal fibrosis, since they are known to act as cellular stress sensors/transducers affecting intracellular Ca(2 (show CA2 Proteins)+) homeostasis/dynamics, and are involved in a broad spectrum of cell pathophysiology including inflammation and tissue remodeling.

  4. Studies provide evidence that the TRPC6-mediated signaling pathway in kidney cells is under control of reactive oxygen species under both physiological and pathological conditions. [review]

  5. SARAF (show TMEM66 Proteins) modulates TRPC1 (show TRPC1 Proteins), but not TRPC6, channel function in a STIM1 (show STIM1 Proteins)-independent manner

  6. Functional interaction of upregulated CaSR (show CASR Proteins) and upregulated TRPC6 in pulmonary artery smooth muscle cells from idiopathic pulmonary arterial hypertension patients may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling.

  7. Our comprehensive analysis of human disease-causing TRPC6 mutations reveals loss of TRPC6 function as an additional concept of hereditary focal segmental glomerulosclerosis and provides molecular insights into the mechanism responsible for the loss-of-function phenotype of TRPC6 G757D in humans

  8. study demonstrated that the various mechanisms regulating MDR in HCC (show FAM126A Proteins) cells are calcium dependent through the TRPC6/calcium/STAT3 (show STAT3 Proteins) pathway. We propose that targeting TRPC6 in HCC (show FAM126A Proteins) may be a novel antineoplastic strategy, especially combined with chemotherapy

  9. n response to stretching (20%), ATP was released only from the foremost cells at the wound edge; it then diffused to the cells behind the wound edge and activated the P2Y (show P2RY1 Proteins) receptors, which caused propagating Ca(2 (show CA2 Proteins)+) waves via TRPC6

  10. Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha (show PKCa Proteins), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 protein (TRPC6) functions.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. We conclude that TRPC6 channels of pancreatic stellate cells are major effector proteins in an autocrine stimulation pathway triggered by hypoxia.

  2. findings link Trpc6-mediated Ca2 (show CA2 Proteins)+ signaling and nitrosative stress in the redox pathobiology of Duchenne muscular dystrophy (show DMD Proteins)

  3. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.

  4. Administration of soluble klotho (show KL Proteins) significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho (show KL Proteins) and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis.

  5. In the present study, we have explored the hypothesis that TRPC3 (show TRPC3 Proteins) and TRPC6 channels expressed in VSMCs may have a differential contribution to the regulation of vascular tone, which could be relevant for the changes in vascular reactivity associated with essential hypertension

  6. This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 (show ORAI2 Proteins) form stromal interaction molecule 2 (STIM2 (show Stim2 Proteins))-regulated neuronal-store-operated Ca(2 (show CA2 Proteins)+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2 (show CA2 Proteins)+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.

  7. ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT (show NFATC1 Proteins) signaling pathway.

  8. the mTORC2 (show CRTC2 Proteins)/Akt (show AKT1 Proteins)/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.

  9. AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.

  10. TRPC3 (show TRPC3 Proteins) and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. These findings suggest that lysoPC induces CaM (show KRIT1 Proteins) phosphorylation at Tyr (show TYR Proteins)(99) by a Src (show SRC Proteins) family kinase and that phosphorylated CaM (show KRIT1 Proteins) activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.

  2. analysis of a TRPC6-TRPC5 (show TRPC5 Proteins) channel cascade that restricts endothelial cell movement

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) interaction partners

  1. Hyperforin (HF)-induced TRPC6 channel activation increased [Ca(2 (show CA2 Proteins)+)]i concentration, inhibited proliferation, and triggered apoptosis in primary neonatal pig glomerular mesangial cells. This apoptosis was not associated with oxidative stress. Activation stimulated NFATc1 (show NFATC1 Proteins) nuclear translocation. HF also increased FasL (show FASL Proteins) level and caspase-8 (show CASP8 Proteins) activity.

  2. Data found that the pig adrenal medulla expressed predominantly TRPC1 (show TRPC1 Proteins), TRPC5 (show TRPC5 Proteins), and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.

Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) Protein Profile

Protein Summary

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Gene names and symbols associated with TRPC6

  • transient receptor potential cation channel subfamily C member 6 (TRPC6)
  • transient receptor potential cation channel, subfamily C, member 6 (Trpc6)
  • transient receptor potential cation channel, subfamily C, member 6a (trpc6a)
  • transient receptor potential cation channel subfamily C member 6 (Trpc6)
  • transient receptor potential cation channel subfamily C member 6 (trpc6)
  • AV025995 protein
  • bZ1P14.9 protein
  • FSGS2 protein
  • LLHWJM002 protein
  • LLHWJM003 protein
  • LLHWJM004 protein
  • mtrp6 protein
  • si:rp71-1p14.9 protein
  • TRP-6 protein
  • trp6 protein
  • trpc6 protein
  • Trrp6 protein

Protein level used designations for TRPC6

TRP-6 , short transient receptor potential channel 6 , transient receptor protein 6 , calcium entry channel , transient receptor potential cation channel, subfamily C, member 6 , transient receptor potential channel subfamily C member 6 , short transient receptor potential channel 6-like

GENE ID SPECIES
7225 Homo sapiens
22068 Mus musculus
89823 Rattus norvegicus
407151 Bos taurus
418989 Gallus gallus
451503 Pan troglodytes
489435 Canis lupus familiaris
563989 Danio rerio
100061175 Equus caballus
100079408 Ornithorhynchus anatinus
100135637 Cavia porcellus
100271728 Sus scrofa
100347206 Oryctolagus cuniculus
100395510 Callithrix jacchus
100479387 Ailuropoda melanoleuca
100545253 Meleagris gallopavo
100554810 Anolis carolinensis
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