anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antibodies

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Proteins (6) and many more products for this protein.

Gene Name	GeneID	UniProt
TRPM2	7226	O94759
TRPM2	294329
TRPM2	28240

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Top anti-TRPM2 Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No.	Reactivity	Host	Conjugate	Application	Quantity	Supplier	Delivery	Price	Details
ABIN259658	Mouse	Rabbit	Un-conjugated	ICC, IHC (fro), IF, IHC, WB	0.1 mL	Log in to see	7 to 9 Days	$444.19	Details
ABIN2781840	Cow	Rabbit	Un-conjugated	IHC, WB	100 μL	Log in to see	2 to 3 Days	$289.00	Details
ABIN153042	Human	Rabbit	Un-conjugated	ICC, IHC (fro), IF, IP, IHC, WB	100 μL	Log in to see	7 to 9 Days	$556.31	Details
ABIN3044470	Human	Rabbit	Un-conjugated	IHC (p), WB	100 μg	Log in to see	4 to 6 Days	$280.00	Details
ABIN443286	Human	Rabbit	Un-conjugated	IHC (p), IHC, WB	100 μL	Log in to see	8 to 11 Days	$514.63	Details
ABIN574048	Human	Goat	Un-conjugated	IHC, IHC (p)	50 μg	Log in to see	11 to 14 Days	$484.00	Details
ABIN490062	Guinea Pig	Rabbit	Un-conjugated	IHC, IHC (p), WB	50 μg	Log in to see	11 to 14 Days	$727.83	Details
ABIN259771	Mouse	Rabbit	Un-conjugated	ICC, IF, WB	0.1 mL	Log in to see	7 to 9 Days	$415.44	Details
ABIN4362934	Mouse	Rabbit	DyLight 550	ICC, IF, IHC, IHC (fro), WB	0.1 mL	Log in to see	7 to 9 Days	$556.31	Details
ABIN153041	Human	Rabbit	Un-conjugated	ICC, IF, IP, WB	100 μL	Log in to see	7 to 9 Days	$556.31	Details

More product categories related to TRPM2 Antibody

Top referenced anti-TRPM2 Antibodies

Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
Show all 8 Pubmed References
Human Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
Show all 4 Pubmed References
Polyclonal TRPM2 Primary Antibody for WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003 (PubMed)
Show all 2 Pubmed References
Human Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
Show all 2 Pubmed References
Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

More Antibodies against TRPM2 Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

TRPM2 (show CLU Antibodies) overexpression in a PDAC cell line (PANC1) promoted cell proliferation, invasion and metastatic ability. TRPM2 (show CLU Antibodies) represents a potential therapeutic target and prognostic marker for patients with PDAC.
The expression of TRPM2 (show CLU Antibodies)-AS was higher in most HCC (show FAM126A Antibodies) tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC (show FAM126A Antibodies) patients. Interfering TRPM2 (show CLU Antibodies)-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC (show FAM126A Antibodies) cell lines.
Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (show CYBB Antibodies)-dependent production of ROS (show ROS1 Antibodies), activation of TRPM2 (show CLU Antibodies) channels, rise in mitochondrial Zn(2+), Drp-1 (show CRMP1 Antibodies) recruitment and abnormal mitochondrial fission.
TRPM2 (show CLU Antibodies) is essential for the survival and migration of squamous cell cancer cells.
Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 (show CLU Antibodies) turnover with the disturbance of autophagy in brain pericyte injury.
oxidative stress activates the TRPM2 (show CLU Antibodies)-Ca(2 (show CA2 Antibodies)+)-CAMK2 (show CAMK2B Antibodies) cascade to phosphorylate BECN1 (show BECN1 Antibodies) resulting in autophagy inhibition
We conclude from these studies that inhibition of ROS (show ROS1 Antibodies) production, and the subsequent abrogation of TRPM2 (show CLU Antibodies)-mediated Ca(2 (show CA2 Antibodies)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.
oxidative stress activated the TRPM2 (show CLU Antibodies)-CaMKII (show CAMK2G Antibodies) cascade to further induce intracellular ROS (show ROS1 Antibodies) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
The work summarized here shows that TRPM2 (show CLU Antibodies) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (show ROS1 Antibodies)
Activation of TRPM2 (show CLU Antibodies) channels, however, caused intracellular release of not only Ca(2 (show CA2 Antibodies)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (show CA2 Antibodies)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

Results demonstrate a critical role for the TRPM2 channel in Abeta42-induced microglial activation and generation of TNF-alpha (show TNF Antibodies): PKC (show PKC Antibodies)/NOX-mediated generation of ROS (show ROS1 Antibodies) and activation of PARP-1 (show PARP1 Antibodies) are required for Abeta42-induced TRPM2 channel activation and, furthermore, the PYK2 (show PTK2B Antibodies)/MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) signaling pathway as a positive feedback mechanism downstream of TRPM2 channel activation facilitates further activation of PARP-1 (show PARP1 Antibodies) and TRPM2 ...
Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (show CYBB Antibodies)-dependent production of ROS (show ROS1 Antibodies), activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 (show CRMP1 Antibodies) recruitment and abnormal mitochondrial fission.
High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.
Trpm2 might promote hyperinflammation in Down Syndrome.
Studied the role of transient receptor potential melastatin 2 (show TRPM3 Antibodies) (TRPM2) in activating caspase-1 (show CASP1 Antibodies) and caspase-1 (show CASP1 Antibodies)-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 (show CASP1 Antibodies) activation and pyrotopsis.
Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.
this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection
Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.
These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.
TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .
heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 Antibodies) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 Antibodies)+) influx that may lead to dysregulated cell growth in ADPKD

TRPM2 Antigen Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

transient receptor potential cation channel subfamily M member 2 (TRPM2) antibody
transient receptor potential cation channel, subfamily M, member 2 (Trpm2) antibody
transient receptor potential cation channel subfamily C member 6 (TRPC6) antibody
transient receptor potential cation channel, subfamily M, member 2 (trpm2) antibody
transient receptor potential cation channel subfamily C member 7 (TRPC7) antibody
short transient receptor potential channel 7 (LOC100443123) antibody
short transient receptor potential channel 7 (LOC100539776) antibody
transient receptor potential cation channel subfamily M member 2 (trpm2) antibody
transient receptor potential cation channel subfamily M member 2 (Trpm2) antibody

9830168K16Rik antibody
C79133 antibody
EREG1 antibody
KNP3 antibody
LTRPC2 antibody
NUDT9H antibody
NUDT9L1 antibody
si:ch73-263b18.1 antibody
Trp7 antibody
TRPC7 antibody
TRPM2 antibody
Trpm2-predicted antibody
Trrp7 antibody

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7 , transient receptor potential channel subfamily C member 7

GENE ID	SPECIES
7226	Homo sapiens
294329	Rattus norvegicus
424835	Gallus gallus
470101	Pan troglodytes
508029	Bos taurus
703611	Macaca mulatta
799412	Danio rerio
100056810	Equus caballus
100083361	Ornithorhynchus anatinus
100124999	Xenopus (Silurana) tropicalis
100341596	Oryctolagus cuniculus
100443123	Pongo abelii
100479298	Ailuropoda melanoleuca
100479364	Ailuropoda melanoleuca
100539776	Meleagris gallopavo
100556895	Anolis carolinensis
28240	Mus musculus
100271727	Sus scrofa
100720314	Cavia porcellus

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