anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antibodies

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRPM2 7226 O94759
TRPM2 294329  
TRPM2 28240  
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Top anti-TRPM2 Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$319.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Goat Un-conjugated IHC, IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Guinea Pig Rabbit Un-conjugated IHC, IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$727.83
Details
Mouse Rabbit Un-conjugated ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of TRPM2 using K562 whole cell lysates Western blot analysis of extracts from mouse brain, using TRPM2 Antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Goat Un-conjugated IHC (p) Immunohistochemistry-Paraffin: TRPM2 Antibody  - Analysis of anti-TRPM2 antibody with human brain, cortex at concentration 3.75 ug/ml. Immunohistochemistry-Paraffin: TRPM2 Antibody  - Analysis of anti-TRPM2 antibody with human pancreas at concentration 3.75 ug/ml. 0.05 mg Log in to see 10 to 13 Days
$559.35
Details

Top referenced anti-TRPM2 Antibodies

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  4. Polyclonal TRPM2 Primary Antibody for WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

More Antibodies against TRPM2 Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Data suggest that TRPM2 plays roles in viability of gastric cancer cell line and in survival of gastric cancer patients; TRPM2 appears to regulate autophagy, mitophagy (mitochondrial degradation), and apoptosis; TRPM2 modulates autophagy through a c-Jun N-terminal kinase (JNK)-dependent mechanism.

  2. TRPM2 overexpression in a PDAC cell line (PANC1) promoted cell proliferation, invasion and metastatic ability. TRPM2 represents a potential therapeutic target and prognostic marker for patients with PDAC.

  3. The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines.

  4. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 recruitment and abnormal mitochondrial fission.

  5. TRPM2 is essential for the survival and migration of squamous cell cancer cells.

  6. Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 turnover with the disturbance of autophagy in brain pericyte injury.

  7. oxidative stress activates the TRPM2-Ca(2+)-CAMK2 cascade to phosphorylate BECN1 resulting in autophagy inhibition

  8. We conclude from these studies that inhibition of ROS production, and the subsequent abrogation of TRPM2-mediated Ca(2+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  9. oxidative stress activated the TRPM2-CaMKII cascade to further induce intracellular ROS production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  10. The work summarized here shows that TRPM2 channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS

  11. Activation of TRPM2 channels, however, caused intracellular release of not only Ca(2+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  12. neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.

  13. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition

  14. findings demonstrate the important function of TRPM2 in modulation of cell survival through mitochondrial ROS, and the potential of targeted inhibition of TRPM2 as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  15. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE.

  16. TRPM2 has a role in the DNA damage response of T cell leukemia cells in a BCL-2 dependent manner

  17. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) channel were more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  18. This is expected to provide a basis for inhibiting TRPM2 for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  19. In a transgenic mouse model of Alzheimer's disease, TRPM2 was involved in neuronal toxicity and memory impairment.

  20. These findings shed new light on the evolution of TRPM2 and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Tumor cell-expressed transient receptor potential channel, melastatin subfamily type 2 (TRPM2) regulates neutrophil chemoattraction via chemokine CXCL2 (CXCL2).

  2. Results demonstrate a critical role for the TRPM2 channel in Abeta42-induced microglial activation and generation of TNF-alpha: PKC/NOX-mediated generation of ROS and activation of PARP-1 are required for Abeta42-induced TRPM2 channel activation and, furthermore, the PYK2/MEK/ERK signaling pathway as a positive feedback mechanism downstream of TRPM2 channel activation facilitates further activation of PARP-1 and TRPM2 ...

  3. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 recruitment and abnormal mitochondrial fission.

  4. High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.

  5. Trpm2 might promote hyperinflammation in Down Syndrome.

  6. Studied the role of transient receptor potential melastatin 2 (TRPM2) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 activation and pyrotopsis.

  7. Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.

  8. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  9. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  10. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  11. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  12. Lysophosphatidylcholine induces intracellular Ca(2+) influx and increases phosphorylation of p38 MAPK via TRPM2, which in turn activates microglia.

  13. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  14. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML chemotherapeutic agents.

  15. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  16. this study demonstrates that the ion channel TRPM] is a temperature sensor in a subpopulation of hypothalamic neurons.

  17. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs) exposure than those from senescent ones.

  18. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP pathway

  19. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

  20. findings provide compelling evidence that F. tularensis catalase restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2+) signaling and limit host immune function.

TRPM2 Antigen Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) antibody
  • transient receptor potential cation channel subfamily C member 7 (TRPC7) antibody
  • transient receptor potential cation channel subfamily M member 2 (trpm2) antibody
  • transient receptor potential cation channel subfamily M member 2 (Trpm2) antibody
  • 9830168K16Rik antibody
  • C79133 antibody
  • EREG1 antibody
  • KNP3 antibody
  • LTRPC2 antibody
  • NUDT9H antibody
  • NUDT9L1 antibody
  • si:ch73-263b18.1 antibody
  • Trp7 antibody
  • TRPC7 antibody
  • TRPM2 antibody
  • Trpm2-predicted antibody
  • Trrp7 antibody

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100479364 Ailuropoda melanoleuca
100556895 Anolis carolinensis
28240 Mus musculus
100720314 Cavia porcellus
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