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Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Additionally we are shipping TMEM59 Proteins (8) and and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal TMEM59 Primary Antibody for IHC, IHC (p) - ABIN442274
Bakulski, Dolinoy, Sartor, Paulson, Konen, Lieberman, Albin, Hu, Rozek: Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. in Journal of Alzheimer's disease : JAD 2012
identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 (show LRP6 Antibodies) and a positive regulator of Wnt (show WNT2 Antibodies) signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt (show WNT2 Antibodies)-FZD assemblies via intramembrane interactions.
The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.
TMEM59 affects amyloid precursor protein (show APP Antibodies) shedding by reducing its acccess to cellular components.
Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY (show NPY Antibodies) and revealed that Dcf1 plays a critical role in energy balance.
MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.
The expression of tmem59 is an important factor contributing to Alzheimer's disease.
Chromosome mapping of 3 proteins (CRSP9 (show MED7 Antibodies), ETF1 (show ETF1 Antibodies) and TMEM59) in swine
Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
transmembrane protein 59
, liver membrane-bound protein
, thymic dendritic cell-derived factor 1