Tripartite Motif Containing 22 Proteins (TRIM22)

The protein encoded by TRIM22 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM22 Antibodies (69) and TRIM22 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM22 10346 Q8IYM9
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Top TRIM22 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

TRIM22 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Tripartite Motif Containing 22 (TRIM22) Interaction Partners

Rhesus Monkey Tripartite Motif Containing 22 (TRIM22) interaction partners

  1. Data show that RNA interference abolished IFN-gamma-induced (show SAMHD1 Proteins) TRIM22 expression, indicating an IRF-1 (show IRF1 Proteins)-dependent expression of TRIM22.

  2. Study shows that human and rhesus TRIM22 localise to different subcellular compartments and that this difference can be assigned to the positively selected B30.2 domain.

Human Tripartite Motif Containing 22 (TRIM22) interaction partners

  1. Suppression of interferon (show IFNA Proteins)-mediated anti-HBV response by single CpG methylation in the 5'-UTR of TRIM22.

  2. Wthis study identified a genetic variation (rs7935564 G allele) in TRIM22 gene, which encodes TRIM22 protein acting like a HIV restriction factor, as being associated with good response to dendritic cell-based immunotherapy

  3. TRIM5 (show TRIM5 Proteins) and TRIM22 single nucleotide polymorphisms are associated to increased odds of significant liver fibrosis and sustained virological response after pegIFNalpha/RBV therapy in human immunodeficiency virus/hepatitis C virus coinfected patients.

  4. Infant with severe IBD characterized by granulomatous colitis and severe perianal disease, we identified a homozygous variant of TRIM22 that affects the ability of its product to regulate NOD2.

  5. Interferon-alpha (show IFNA Proteins)-induced TRIM22 interrupts hepatitis c virus replication by ubiquitinating NS5A.

  6. regulation of FoxO4 (show FOXO4 Proteins) protein expression and cell survival by TRIM22 controls TLR3 (show TLR3 Proteins)-mediated IFN type I gene induction, preventing excessive antiviral response through dsRNA-induced apoptosis.

  7. TRIM22 could interact with IkappaB kinase (IKK)alpha (show CHUK Proteins) but not IKKbeta (show IKBKB Proteins) and could increase the level and phosphorylation of IKKalpha (show CHUK Proteins) through its really interesting new gene (RING) and spla-ryanodine receptor (show RYR3 Proteins) (SPRY) domains.

  8. Demonstrated that TRIM22 acts as a negative regulator of HIV-1 replication via inhibition of basal Sp1 (show PSG1 Proteins)-driven proviral transcription.

  9. propose that TRIM22 is a direct target gene of PR and that it can mediate progesterone actions in uterine cells

  10. Data show that capsid protein p24-DsRed-Monomer was co-localized with tripartite motif containing 22 (TRIM22)-EGFP in HEK293T cells.

TRIM22 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with TRIM22

  • tripartite motif containing 22 (TRIM22)
  • GPSTAF50 protein
  • RNF94 protein
  • STAF50 protein

Protein level used designations for TRIM22

E3 ubiquitin-protein ligase TRIM22 , tripartite motif-containing 22 , tripartite motif containing 22 , 50 kDa-stimulated trans-acting factor , RING finger protein 94 , staf-50 , stimulated trans-acting factor (50 kDa) , tripartite binding motif 22 , tripartite motif protein TRIM22 , tripartite motif-containing protein 22

450985 Pan troglodytes
485284 Canis lupus familiaris
713814 Macaca mulatta
100137325 Papio anubis
100294624 Pongo abelii
100589657 Nomascus leucogenys
10346 Homo sapiens
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