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Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
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the role of the human TBCE and TBCB chaperones in alpha-tubulin (show TUBA4A Antibodies)-beta-tubulin (show TUBB Antibodies) dissociation, was investigated.
results support a role for MAP1 (show MASP1 Antibodies) proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
Overexpression of TBCB leads to the decreased localization of p150 (show ABL1 Antibodies) to the microtubule network that might result in a functional modulation of this protein complex.
TBCB localizes at spindle and midzone microtubules during mitosis.
These findings identified TCoB as the third cytoskeleton protein (show SPTBN1 Antibodies) to be nitrated and suggest a previously undescribed mechanism, whereby growth factor signaling may coordinately integrate nitric oxide signaling in the regulation of microtubule dynamics.
TBCB functions as a microtubule density regulator in microglia during activation, and provide an insight into understanding of mechanisms controlling microtubule reorganization during microglial transition between phenotypes.
Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules; neither TBCB abundance nor microtubule organization or densities are altered in giant axonal neuropathy (show GAN Antibodies) mutant fibroblasts.
We show that TBCB overexpression depolymerizes microtubules. We found that this function is based on the ability of TBCB to form a binary complex with TBCE (show TBCE Antibodies) that greatly enhances the efficiency of this cofactor to dissociate tubulin (show TUBB Antibodies) in vivo and in vitro.
Results indicate a developmental function for the tubulin (show TUBB Antibodies)-binding cofactor B (dTBCB) gene that is essential for viability and microtubules (MTs (show NEU2 Antibodies))-dependent cell polarity, but not cell division.
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
cytoskeleton associated protein 1
, cytoskeleton-associated protein 1
, cytoskeleton-associated protein CKAPI
, tubulin-folding cofactor B
, tubulin-specific chaperone B
, liver cancer related protein
, tubulin folding cofactor B
, tubulin-folding cofactor B-like