Tyrosyl-tRNA Synthetase Proteins (Yars)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Additionally we are shipping Tyrosyl-tRNA Synthetase Antibodies (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Yars 8565 P54577
Yars 313047 Q4KM49
Yars 107271 Q91WQ3
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Top Tyrosyl-tRNA Synthetase Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human GST tag Tyrosyl-tRNA Synthetase (Yars) (AA 2-528), (full length) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$492.31
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,505.33
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$672.00
Details
Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 9 to 11 Days
$350.30
Details

Yars Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Tyrosyl-tRNA Synthetase (Yars) Interaction Partners

Human Tyrosyl-tRNA Synthetase (Yars) interaction partners

  1. conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production.

  2. Platelet replenishment by YRS(ACT) is independent of thrombopoietin (TPO), as evidenced by expansion of the megakaryocytes from induced pluripotent stem cell-derived hematopoietic stem cells from a patient deficient in TPO signaling.

  3. These YARS variants occur in the catalytic domain and the C-terminal domain, respectively. Mutations in YARS have been previously associated with an autosomal dominant form of Charcot-Marie-Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy.

  4. Studied the structural effect of three Charcot-Marie-Tooth disease-causing mutations in tyrosyl-tRNA synthetase. The mutations do not induce changes in protein secondary structures, or shared effects on oligomerization state and stability. However, all mutations provide access to a surface masked in the wild-type enzyme, and that access correlates with protein misinteraction.

  5. Data show that the internal deletion of tyrosyl-tRNA synthetase TyrRSDeltaE2-4 splice variants (SVs) gave an alternative, neomorphic dimer interface 'orthogonal' to that of native TyrRS.

  6. Expression of CMT-mutant tyrosyl-tRNA synthetase in Drosophila impairs protein translation.

  7. Computational modeling of molecular dynamics of G41R mutant form of human tyrosyl-tRNA synthetase, assosiated with Charcot-Marie-Tooth neuropathy has been presented.

  8. the association of rare YARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy

  9. This study presents genetic evidence for common mutant-specific interactions between two CMT-associated aminoacyl-tRNA synthetases, lending support for a shared mechanism responsible for the synthetase-induced peripheral neuropathies.

  10. rhTyrRS promotes migration and aggregation of megakaryocytes to the bone marrow niche

  11. nuclear-localized TyrRS activates transcription factor E2F1 to upregulate the expression of DNA damage repair genes such as BRCA1 and RAD51.

  12. A major difference between the first- and second-generation tRNA synthetases (RSs) is that the second-generation RSs have an active site more compatible with tyrosine binding.

  13. The full length tyrosyl-tRNA synthetase lacks its cytokine activity because of the interactions between N-terminal and the C-terminal modules, which protect the ELR cytokine motif.

  14. Naturally occurring fragments of the two proteins involved in translation, TyrRS and TrpRS, have opposing activities on angiogenesis.

  15. Nuclear import of TyrRS is regulated by tRNA(Tyr).

  16. Dominant Intermediate Charcot-Marie-Tooth disorder is not due to a catalytic defect in tyrosyl-tRNA synthetase.

  17. Expression of tyrosyl-tRNA synthetase (YARS) DI-CMTC associated mutations (G41R, E196K,153-156delVKQV)in Drosophila leads to neuronal dysfunction.

  18. role in catalyzing tyrosyl-adenylate formation

  19. replacement of second lysine in KMSKS signature sequence by potassium

  20. role in inducing angiogenesis

Mouse (Murine) Tyrosyl-tRNA Synthetase (Yars) interaction partners

  1. conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production.

Cow (Bovine) Tyrosyl-tRNA Synthetase (Yars) interaction partners

  1. conformational transition of Trp144 from buried native state into highly relaxing polar solvent environment

Tyrosyl-tRNA Synthetase (Yars) Protein Profile

Protein Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.

Gene names and symbols associated with Tyrosyl-tRNA Synthetase Proteins (Yars)

  • tyrosyl-tRNA synthetase (YARS)
  • tyrosyl-tRNA synthetase (Yars)
  • tyrosyl-tRNA synthetase (yars)
  • tyrosyl-tRNA synthetase L homeolog (yars.L)
  • tyrosyl-tRNA synthetase, putative (MAL8P1.125)
  • tyrosine--tRNA ligase (MEFER_RS04475)
  • tyrosine--tRNA ligase, cytoplasmic (LOC413909)
  • tyrosine--tRNA ligase, cytoplasmic (LOC100163888)
  • tyrosyl-tRNA synthetase (LOC100282315)
  • AL024047 protein
  • AU018965 protein
  • cb204 protein
  • cmtdic protein
  • GB10789 protein
  • tyrrs protein
  • wu:fk52b08 protein
  • YARS protein
  • yrs protein
  • yts protein

Protein level used designations for Tyrosyl-tRNA Synthetase Proteins (Yars)

tyrosine tRNA ligase 1, cytoplasmic , tyrosine--tRNA ligase, cytoplasmic , tyrosyl--tRNA ligase , tyrosyl-tRNA synthetase, cytoplasmic , Tyrosyl-tRNA synthetase, cytoplasmic , tyrRS , tyrosyl-tRNA synthetase , ACYPI004940

GENE ID SPECIES
8565 Homo sapiens
100173008 Pongo abelii
478148 Canis lupus familiaris
313047 Rattus norvegicus
107271 Mus musculus
368235 Danio rerio
419666 Gallus gallus
709003 Macaca mulatta
469266 Pan troglodytes
448444 Xenopus (Silurana) tropicalis
281581 Bos taurus
380438 Xenopus laevis
2655248 Plasmodium falciparum 3D7
8365568 Methanocaldococcus fervens AG86
413909 Apis mellifera
100163888 Acyrthosiphon pisum
100282315 Zea mays
100722635 Cavia porcellus
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