Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity.
UBX Domain Protein 1 (UBXN1) Antigen Profile
Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.
Gene names and symbols associated with UBXN1
UBX domain protein 1 (UBXN1) antibody
UBX domain protein 1 (Ubxn1) antibody
UBX domain protein 1 (ubxn1) antibody
Protein level used designations for UBXN1
SAPK substrate protein 1
, UBA/UBX 33.3 kDa protein
, UBX domain-containing protein 1
, protein 2B28