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Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. Additionally we are shipping UBXN6 Proteins (5) and many more products for this protein.
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Upon damage, p97 (show EIF4G2 Antibodies) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA (show PLAA Antibodies), and the deubiquitinating enzyme YOD1 (show YOD1 Antibodies), which we term ELDR components for Endo-Lysosomal Damage Response.
UBXD1-N intercalates into the p97 (show EIF4G2 Antibodies)-ND1 (show MT-ND1 Antibodies) interface, thereby modulating interdomain communication of p97 (show EIF4G2 Antibodies) domains and its activity with relevance for disease pathogenesis
Data indicate that endosomal trafficking of CAV1 (show CAV1 Antibodies) depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP (show vcp Antibodies)-UBXD1.
UBXD1 modulates the trafficking of ERGIC-53 (show LMAN1 Antibodies)-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53 (show LMAN1 Antibodies).
Data show that expression of VCP (show vcp Antibodies) mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 (show CAV1 Antibodies) transport at the limiting membrane of enlarged endosomes in cultured cells.
UBXD1 is a novel co-factor of the human p97 ATPase (show vcp Antibodies).
An additional p97 (show EIF4G2 Antibodies) binding site in UBXD1 that competed with the p47 (show ING1 Antibodies) cofactor for binding to the N domain of p97 (show EIF4G2 Antibodies) was identified.
these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP.
Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).
UBX domain containing 1
, UBX domain-containing protein 6
, UBX domain protein 6
, UBX domain-containing 1
, UBX domain-containing 2
, UBX domain-containing protein 1