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General vesicular transport factor required for intercisternal transport in the Golgi stack\; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. Additionally we are shipping USO1 Homolog, Vesicle Docking Protein Antibodies (103) and and many more products for this protein.
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USO1 deficiency results in Golgi disruption and early embryonic lethality in mice.
The p115 structures show a novel alpha-solenoid architecture constructed of 12 armadillo (show PKP1 Proteins)-like, tether-repeat, alpha-helical tripod motifs.
USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker.
USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells.
P115 promotes proliferation of gastric cancer cells through an interaction with MIF (show AMH Proteins).
Scyl1 (show CCL13 Proteins) interacts with 58K/formiminotransferase cyclodeaminase (FTCD (show FTCD Proteins)) and golgin p115, and is required for the maintenance of Golgi morphology.
p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis
a conserved tethering function of the Golgi protein (show GOLPH3 Proteins) p115 CTF (show NFIA Proteins) which promotes p53 (show TP53 Proteins)-ERK (show EPHB2 Proteins) interaction for the amplification of the apoptotic signal.
Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation.
p115 acts directly, rather than via a tether, to catalyze trans-SNARE (show NAPA Proteins) complex formation preceding membrane fusion.
The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks.
The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively.
General vesicular transport factor required for intercisternal transport in the Golgi stack\; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
USO1 vesicle docking protein homolog
, USO1 homolog, vesicle docking protein
, USO1 vesicle docking protein homolog (yeast)
, vesicle docking protein p115
, general vesicular transport factor p115
, protein USO1 homolog
, transcytosis associated protein p115
, transcytosis-associated protein
, vesicle docking protein, 115 kDa
, vesicle-docking protein
, membrane tethering protein p115
, vesicular transport factor p115
, transcytosis associated protein