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VCX3A belongs to the VCX\\/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells.
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Our data demonstrate that VCX-A can regulate mRNA stability and that it is an example of a tissue-specific decapping regulator.
two different deletion patterns were observed: the first group included 62 patients with deletion of VCX3A & VCX (show VCX Antibodies) genes. The second group included 18 patients with breakpoints at several regions on either side of the STS (show STS Antibodies) gene not including the VCX3A gene.
We demonstrate that VCX-A can specifically bind a subset of mRNAs involved in neuritogenesis and is also capable of promoting translational silencing.
This gene belongs to the VCX\\/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number\\\\; different individuals may have a different number of VCX genes. VCX\\/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX\\/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit.
variable charge X-linked protein 3
, variable charge protein on X with eight repeats
, variably charged X-A
, variably charged protein X-A