anti-Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) Antibodies

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Additionally we are shipping ZFP36 Kits (11) and ZFP36 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ZFP36 7538 P26651
ZFP36 22695 P22893
ZFP36 79426 P47973
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Top anti-ZFP36 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ZFP36 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  TTP  Sample Type:  Fetal Lung lysates  Antibody Dilution:  0.2ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ZFP36 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Lung Rabbit Anti-ZFP36 antibody        Paraffin Embedded Tissue:  Human Heart cell   Cellular Data:  Epithelial cells of renal tubule  Antibody Concentration:   4.0-8.0 ug/ml  Magnification:   400X 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB IHC Information: Paraffin embedded small intestine, submucosal plexus tissue, tested with an antibody dilution of 5 ug/ml. WB Suggested Anti-ZFP36 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-ZFP36 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  PANC1 cell lysate ZFP36 is supported by BioGPS gene expression data to be expressed in PANC1 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ZFP36 Antibody (Center) (ABIN652459) in mouse stomach tissue lysates (35 µg/lane).ZFP36 (arrow) was detected using the purified polyclonal antibody.(8 µg/mL) Formalin-fixed and paraffin-embedded human brain tissue reacted with ZFP36 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of ZFP36 Antibody (Center) (ABIN652899) in WiDr cell line lysates (35 µg/lane). ZFP36 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with ZFP36 antibody ABIN214153 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-ZFP36 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other for ... 50 μg Log in to see 11 to 14 Days
$727.83
Details

Top referenced anti-ZFP36 Antibodies

  1. Cow (Bovine) Polyclonal ZFP36 Primary Antibody for WB - ABIN2775764 : Esclatine, Taddeo, Roizman: Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. in Journal of virology 2004 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ZFP36 Interaction Partners

Human Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. P38 activation repressed the cooperation of TTP with Ago2, thus ensuring that ARE-mRNA does not associate with processing bodies and remains stable.

  2. Overexpression of miRNA-29c in podocytes resulted in an increase in inflammatory cytokines and inhibition of miRNA-29c by using its inhibitor reduced the inflammatory cytokines in podocytes. Finally, miRNA-29c promoted the progression of diabetic nephropathy (DN) by targeting TTP, providing a target for a therapeutic intervention of DN.

  3. Data indicate that the angiopoietin-like protein 4 (ANGPTL4)-mediated upregulation of tristetraprolin expression regulates the stability of chemokines in human colon epithelial cells.

  4. PD-L1 is a critical TTP-regulated factor that contributes to inhibiting antitumor immunity.

  5. The role of TTP in human cancers and immunity.[review]

  6. Findings reveal tristetraprolin, which is known to bind COX-2 mRNA and promote its rapid degradation, as regulator of COX-2 expression in influenza A viruses (IAV) infection. During IAV replication and viral RNA accumulation TTP mRNA synthesis was induced, resulting in reduced COX-2 levels.

  7. our data demonstrate that TTP acts as a regulator of mitochondrial dynamics through enhancing degradation of alpha-Syn mRNA in cancer cells. This finding will increase understanding of the molecular basis of mitochondrial dynamics.

  8. Suggest that TTP is an important prognostic indicator for prostate cancer, and augmenting TTP function would effectively disable the metabolism and proliferation of aggressive prostate tumors.

  9. RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin.

  10. Because TTP also represses IL-1beta expression, it is a dual inhibitor of the IL-1beta system, regulating expression of the cytokine and the upstream controller NLRP3

  11. Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta, IL-6 and TNFalpha mRNA degradation, destabilized TNFalpha mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP).

  12. TTP was demonstrated to destabilize the VEGF mRNA in ARPE-19 cells under hypoxic conditions. Furthermore, CM from TTP-overexpressing ARPE-19 cells suppressed tube formation in HUVECs.

  13. this study shows that TTP is down-regulated in glioma tissue samples and cell lines, and is associated with diminished survival in glioma patients

  14. TTP inhibited the proliferation, migration, and invasion of gastric cancer cell lines through regulation of IL-33.

  15. Results suggest that ZFP36 proteins might control reepithelialization and angiogenesis in the skin in a multimodal manner.

  16. Our data offer the convincing evidence for the first time that the aberrant expressions of ZFP36 and SOCS3 may be involved into the progression and patients' prognosis of prostate cancer

  17. Low TTP expression is associated with epithelial-mesenchymal transition in cancer.

  18. PP2A activators boost the anti-inflammatory function of TTP and have implications for future pharmacotherapeutic strategies to combat inflammation in respiratory disease.

  19. The mRNA destabilizing activity of TTP was increased when the partially disordered RNA binding domain (RBD) of TTP was replaced with the fully structured RBD of TIS11d, indicating that differences in the folded state of the RBD affect the activity of the proteins in the cell.

  20. Tristetraprolin induces cell cycle arrest in breast tumor cells by targeting AP-1/c-Jun and NF-kappaB/RelA pathway.

Pig (Porcine) Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. direct interaction between TTP protein and porcine TNF-alpha mRNA ARE probe

Mouse (Murine) Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) interaction partners

  1. mRNA-binding protein tristetraprolin (TTP) is induced by iron deficiency and degrades mRNAs of mitochondrial Fe/S-cluster-containing proteins, specifically Ndufs1 in complex I and Uqcrfs1 in complex III, to match the decrease in Fe/S-cluster availability.

  2. Expression of the RNA-binding protein, tristetraprolin (TTP) was down-regulated in response to calcineurin inhibition.

  3. by utilizing Ttp-/- mice we demonstrated the in vivo anti-inflammatory role of Ttp in radiation pneumonitis.

  4. Results suggest that RNA-binding proteins such as TTP are expressed and perhaps involved in the modulation of inflammation-induced pregnancy pathologies.

  5. The authors found that the endogenous Zfp36 directly interacts with the cytoplasmic poly(A)-binding protein. Importantly, this interaction is required for the translational repression of Zfp36's target mRNAs in resolving inflammation.

  6. degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response

  7. Results suggest that tristetraprolin (TTP) as a cytoskeletal regulator is required for spindle morphology/chromosome alignment and actin polymerization in oocytes.

  8. RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin.

  9. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript.

  10. Posttranscriptional gene regulation by TTP schedules the termination of the antimicrobial engagement of neutrophils.

  11. the gain-of-function mutation of TTP impairs IL-10-mediated negative feedback control of macrophage function in vitro.

  12. Studies indicate that mice lacking tristetraprolin (TTP) developed a spontaneous and pervasive inflammatory syndrome.

  13. The data demonstrate that cigarette smoke exposure reduces TTP expression and impairs TTP function, resulting in significantly increased TNF-alpha mRNA stability and excessive TNF-alpha expression in alveolar macrophages and epithelial cells.

  14. study uncovers a role of TTP as a suppressor of feedback inhibitors of inflammation and highlights the importance of fine-tuned TTP activity-regulation by MK2 in order to control the pro-inflammatory response

  15. TTP is not involved in LPS-mediated destabilization of PLCbeta-2 mRNA in macrophages

  16. Zinc Finger Protein 36 deficiency has profound effects on the splenic transcriptome.

  17. Mouse LARP4 is regulated by TNF-alpha in a TTP-dependent manner.

  18. Regulation of mRNAs by tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis.

  19. Tristetraprolin limits inflammatory cytokine production in tumor-associated macrophages in an mRNA decay-independent manner.

  20. Dominant suppression of inflammation can be achieved via targeted mutation of the mRNA destabilizing protein tristetraprolin.

ZFP36 Antigen Profile

Protein Summary

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Gene names and symbols associated with ZFP36

  • ZFP36 ring finger protein (ZFP36) antibody
  • ZFP36 ring finger protein L homeolog (zfp36.L) antibody
  • tristetraproline (EDI_287240) antibody
  • Tristetraproline (Bm1_42085) antibody
  • tristetraproline (LOAG_03119) antibody
  • similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth (ZFP36) antibody
  • ZFP36 ring finger protein (zfp36) antibody
  • zinc finger protein 36 (Zfp36) antibody
  • ZFP36 ring finger protein (Zfp36) antibody
  • C3H-1 antibody
  • g0s24 antibody
  • Gos24 antibody
  • Nup475 antibody
  • rnf162a antibody
  • Tis11 antibody
  • TIS11D antibody
  • TISII antibody
  • Ttp antibody
  • Zfp-36 antibody
  • ZFP36 antibody

Protein level used designations for ZFP36

G0/G1 switch regulatory protein 24 , growth factor-inducible nuclear protein NUP475 , tristetraprolin , tristetraproline , zinc finger protein 36 homolog , zinc finger protein 36, C3H type, homolog , zinc finger protein, C3H type, 36 homolog , CCCH zinc finger protein C3H-1 , Tristetraproline , TIS11 , TTP , zfp-36 , zinc finger protein homologous to Zfp-36 in mouse , similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth , zinc finger protein 36, C3H type, homolog (mouse) , CCCH (CX8CX5CX3H) zinc finger domain RNA-binding protein , TPA-induced sequence 11 , TNF alpha inhibitor , Tax interacting protein

GENE ID SPECIES
7538 Homo sapiens
398102 Xenopus laevis
5879635 Entamoeba dispar SAW760
6103302 Brugia malayi
9940506 Loa loa
282127 Bos taurus
698280 Macaca mulatta
736203 Pan troglodytes
100127733 Xenopus (Silurana) tropicalis
100316849 Sus scrofa
22695 Mus musculus
79426 Rattus norvegicus
484510 Canis lupus familiaris
443283 Ovis aries
100733110 Cavia porcellus
100340391 Oryctolagus cuniculus
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