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May be involved in transcriptional regulation.. Additionally we are shipping and many more products for this protein.
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Results show association between AAO of AD and both ZBTB4 and NCSTN. ZBTB4 is a transcriptional repressor that regulates the cell cycle, including the apoptotic response to amyloid beta, while NCSTN is part of the gamma secretase complex, known to influence amyloid beta production.
In vitro, ZBTB4 overexpression inhibited cell proliferation, and induced cell cycle arrest at G1 phase and apoptosis in SK-ES-1 and RD-ES cells.
Our results establish the epigenetic regulator ZBTB4 as an essential component in maintaining genomic stability
Thus, EZH2 is reciprocally regulated by a novel signaling network consisting of Sp proteins, oncogenic miRs and ZBTB4, and modulation of this gene network is a novel therapeutic approach for treatment of breast cancer and possibly other cancers.
ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival
the human zinc-finger protein ZBTB4 binds methylated DNA in a sequence-specific manner.
ZBTB4 binds methylated methylated CpGs in vitro and in vivo and represses transcrption.
These data suggest that Zbtb4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53.
Results show that overexpressing HIPK2 causes the degradation of ZBTB4, whereas overexpressing a kinase-deficient mutant of HIPK2 has no effect.
May be involved in transcriptional regulation.
KAISO-like zinc finger protein 1
, zinc finger and BTB domain-containing protein 4