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May be involved in transcriptional regulation.. Additionally we are shipping and many more products for this protein.
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In vitro, ZBTB4 overexpression inhibited cell proliferation, and induced cell cycle arrest at G1 phase and apoptosis in SK-ES-1 (show C21orf33 Antibodies) and RD-ES cells.
Our results establish the epigenetic regulator ZBTB4 as an essential component in maintaining genomic stability
Thus, EZH2 (show EZH2 Antibodies) is reciprocally regulated by a novel signaling network consisting of Sp proteins, oncogenic miRs and ZBTB4, and modulation of this gene network is a novel therapeutic approach for treatment of breast cancer and possibly other cancers.
ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival
the human zinc-finger protein ZBTB4 binds methylated DNA in a sequence-specific manner.
ZBTB4 binds methylated methylated CpGs in vitro and in vivo and represses transcrption.
These data suggest that Zbtb4 is a critical determinant of the cellular response to p53 (show TP53 Antibodies) activation and reinforce the notion that p21Cip1 (show CDKN1A Antibodies) can provide an essential survival signal in cells with activated p53 (show TP53 Antibodies).
Results show that overexpressing HIPK2 (show HIPK2 Antibodies) causes the degradation of ZBTB4, whereas overexpressing a kinase-deficient mutant of HIPK2 (show HIPK2 Antibodies) has no effect.
we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties
May be involved in transcriptional regulation.
KAISO-like zinc finger protein 1
, zinc finger and BTB domain-containing protein 4