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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Additionally we are shipping ZBTB7A Kits (11) and ZBTB7A Proteins (4) and many more products for this protein.
Showing 10 out of 111 products:
Human Polyclonal ZBTB7A Primary Antibody for IP, IHC - ABIN152180
Aggarwal, Hunter, Aggarwal, Silva, Davey, Murphy, Agrawal: Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers. in Experimental and molecular pathology 2010
Show all 3 Pubmed References
Human Polyclonal ZBTB7A Primary Antibody for IHC (p), IP - ABIN152181
Sebestyén, Sticz, Márk, Hajdu, Timár, Nemes, Nagy, Váradi, Kopper: Activity and complexes of mTOR in diffuse large B-cell lymphomas--a tissue microarray study. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012
Human Polyclonal ZBTB7A Primary Antibody for IF (p), IHC (p) - ABIN729448
Zhao, Yao, Li, An, Chen, Sun, Kang, Wang, Hu: Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14(ARF)-MDM2-p53 pathway. in Medical oncology (Northwood, London, England) 2014
Human Polyclonal ZBTB7A Primary Antibody for IHC, IHC (p) - ABIN4366685
Lunardi, Ala, Epping, Salmena, Clohessy, Webster, Wang, Mazzucchelli, Bianconi, Stack, Lis, Patnaik, Cantley, Bubley, Cordon-Cardo, Gerald, Montironi, Signoretti, Loda, Nardella, Pandolfi: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. in Nature genetics 2013
Variants of ZBTB7A (LRF) and its beta-globin (show HBB Antibodies) gene cluster binding motifs in sickle cell anemia/
This analysis complements the understanding of the mutational landscape of core binding factor (show CBFB Antibodies) acute myeloid leukemia (show BCL11A Antibodies), and has led to the identification of novel ZBTB7A mutations in t(8;21) acute myeloid leukemia (show BCL11A Antibodies) subgroup.
Lymphoma-related factor mediates the protease-activated receptor 2 (show F2RL1 Antibodies)-suppressed p53 (show TP53 Antibodies) expression in the cancer cells and binds DAP5 (show EIF4G2 Antibodies) to interfere with the gene transcription of p53 (show TP53 Antibodies) in colon cancer cells.
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
Mutation in ZBTB7A is associated with core-binding factor (show CBFB Antibodies) acute myeloid leukemia (show BCL11A Antibodies).
Zbtb7a knockdown by siRNA suppressed cell proliferation and i (show MLXIP Antibodies)nduced G1 cell cycle arrest and apoptosis (show MLXIP Antibodies) in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.
Data suggest that microRNA miR (show MLXIP Antibodies)-520e directly targets to the 3'-untranslated region (3'-UTR (show UTS2R Antibodies)) of zinc finger and BTB domain containing 7A protein (Zbtb7a).
CCAT2 promotes tumorigenesis by over-expression of Pokemon.
High FBI-1 expression is associated with hepatocellular carcinoma.
there is an auto-regulatory circuit consisting of miR (show MLXIP Antibodies)-125 and Pokemon, which promotes the progression of HCC (show FAM126A Antibodies) and may be a promising therapeutic target in clinical HCC (show FAM126A Antibodies) treatment
this study shows that Thpok (show ZBTB7B Antibodies) and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
This study identified Zbtb7a as a novel direct target for miR (show MLXIP Antibodies)-125a by gene expression profiling in miR (show MLXIP Antibodies)-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (show ZBTB7B Antibodies) and LRF redundantly maintain CD4 (show CD4 Antibodies)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (show MLXIP Antibodies)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (show NOTCH1 Antibodies)/Dll4 (show DLL4 Antibodies)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
T cells lacking Thpok (show ZBTB7B Antibodies), which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites
study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF