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ZBTB7B encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. Additionally we are shipping Zinc Finger and BTB Domain Containing 7B Proteins (3) and Zinc Finger and BTB Domain Containing 7B Kits (1) and many more products for this protein.
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Human Monoclonal ZBTB7B Primary Antibody for ICC, IHC - ABIN1724728
Galéra, Musso, Ducy, Karsenty: c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. in Proceedings of the National Academy of Sciences of the United States of America 1994
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Human Polyclonal ZBTB7B Primary Antibody for IF, WB - ABIN1882155
Matsumoto, Horiike, Ohshiro, Yamamoto, Sasaki, Tsutsumi, Kobayashi, Shimizu, Uchiyama, Kuroda, Nomura, Shimazaki, Taniwaki: Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis. in American journal of clinical pathology 2010
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Cow (Bovine) Polyclonal ZBTB7B Primary Antibody for IHC, WB - ABIN2777563
Widom, Culic, Lee, Korn: Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression. in Gene 1997
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a novel pathway by which TIP60 (show KAT5 Antibodies) and ThPOK synergistically suppresses Eomes (show EOMES Antibodies) function and IFNgamma production, which could contribute to the regulation of inflammation.
ThPOK may be considered a central regulator of the earliest events in the immune system during colorectal cancer development, decreasing the immune response against cancer cells.
The distal regulatory element (DRE (show SUFUH Antibodies)) in the Thpok gene also functions as a transcriptional enhancer, with DNA sequences specifically responsible for thymic enhancer activity.
ThPOK transgene stably represses CD8 (show CD8A Antibodies) gene expression through the deacetylation of Cd8 (show CD8A Antibodies) loci in CD4 (show CD4 Antibodies) cell lineage commitment.
The p65 (show GORASP1 Antibodies) subunit of NF-kappaB (show NFKB1 Antibodies) inhibits COL1A1 (show COL1A1 Antibodies) gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1 (show PSG1 Antibodies), and Sp3 (show SP3 Antibodies)).
impairment of Lck (show LCK Antibodies)-mediated CD4 (show CD4 Antibodies) coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis
Thymoma neoplastic epithelial cells can induce Th-POK expression in T-cell subsets similarly to the normal thymic epithelial cells. In addition, there was no significant difference in Runx3 (show RUNX3 Antibodies) expression in T-cell subsets between normal thymi and thymomas.
These data suggest that the regulation of COL1A1 (show COL1A1 Antibodies) gene transcription in human dermal fibroblasts involves a complex machinery that implicates at least three transcription proteins, hc-Krox, Sp1 (show PSG1 Antibodies), and Sp3 (show SP3 Antibodies).
Chondroitin sulphate and its derived hydrolytic fragments (CSf (show CSF2 Antibodies)) repress COL1A1 (show COL1A1 Antibodies) gene transcription through a -112/-61 bp sequence upstream the start site of transcription and imply hc-Krox and Sp1 (show PSG1 Antibodies) transcription factors.
Runx and ThPOK role in mechanisms of lineage-specific gene regulation in the process of T-cell commitments[review]
this study shows that Thpok and LRF (show ZBTB7A Antibodies) are redundantly required to maintain the size and functions of the postthymic Treg pool
Together, these results suggest a novel mechanism regulating endothelial PATZ1 (show ZNF278 Antibodies) expression based on the down-regulation of miR (show MLXIP Antibodies)-24 expression caused by hyperglycemia. Interfering with PATZ1 (show ZNF278 Antibodies) expression via miRNAs or miRNA mimics could potentially represent a new way to target endothelial PATZ1 (show ZNF278 Antibodies)-dependent signaling of vascular dysfunction in diabetes.
Runx3 (show RUNX3 Antibodies) is crucial for the phenotypic and functional changes observed in ThPok-deficient invariant natural killer T cells.
present evidence that ectopic ThPOK expression gives rise to a preleukemic and self-perpetuating DN4 lymphoma precursor population
Data indicate that transcription factors Thpok and LRF (show ZBTB7A Antibodies) redundantly maintain CD4 (show CD4 Antibodies)+ lineage integrity.
induction of SOCS (show CISH Antibodies)-encoding genes is the main mechanism by which ThPOK imposes the CD4 (show CD4 Antibodies)(+) lineage fate in the thymus
The role of TCF-1 (show HNF1A Antibodies) and LEF-1 (show LEF1 Antibodies) in the CD4 (show CD4 Antibodies)-versus-CD8 (show CD8A Antibodies) lineage 'choice' was mediated in part by direct positive regulation of the transcription factor Th-POK
These findings imply that long-lasting T-cell receptor signals are needed to establish stable Thpok expression activity to commit to helper T-cell fate.
Gata3 (show GATA3 Antibodies) promotes Cd4 (show CD4 Antibodies) expression in Thpok-deficient thymocytes.
Data indicate that Valpha14 invariant natural killer T (Valpha14i NKT (show CTSL1 Antibodies)) cells from Th-POK-mutant helper deficient (hd/hd (show HTT Antibodies)) mice have increased transcripts of genes normally expressed by Th17 and NKT17 cells.
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.
T-helper-inducing POZ/Krueppel-like factor
, krueppel-related zinc finger protein cKrox
, zinc finger and BTB domain containing 15
, zinc finger and BTB domain-containing protein 7B
, zinc finger protein 67 homolog
, zinc finger protein 857B
, zinc finger protein Th-POK
, T helper-inducing POZ/Krueppel factor
, Vzinc finger and BTB domain containing 7B
, zinc finger protein 67
, zinc finger and BTB domain containing 7B
, kruppel-related zinc finger protein hcKrox