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ZNRD1 encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I.
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Findings suggest a tumor suppressor function for ZNRD1 gene and a tumor contributor function for long noncoding RNAs (IncRNAs) ZNRD1-AS1 in the process of carcinogenesis of lung cancer.
The minor alleles of rs2395029, rs9264942, and rs3689068 in the HCP5 and HLA-C, and ZNRD1 genes associate with lower viral loads (VL) among antiretroviral-naive individuals and with shorter time to first VL less 51 copies/ml during anti-HIV therapy.
ZNRD1 regulatory SNPs may be susceptibility makers for risk of both chronic HBV infection and HCC (show FAM126A Proteins).
This study provides novel evidence that ZNRD1 polymorphism may confer host resistance to HIV-1 acquisition.
A miR (show MLXIP Proteins)-508-5p/ZNRD1/ABCB1 (show ABCB1 Proteins) regulatory loop has a critical role in MDR in gastric cancer.
Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan.
Nominal associations were found between ZNRD1 rs1150740 and risk of AERD via codominant and dominant genetic inheritance (P=.03; odds ratio, 1.14 [1.14-10.16]).
The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR (show MLXIP Proteins)-214 and down-regulate the expression of miR (show MLXIP Proteins)-296.
siRNA-based functional analysis showed that ZNRD1 down-regulation by siRNA or shRNA impaired HIV-1 replication at the transcription level in both lymphoid and nonlymphoid cells.
ZNRD1 gene displays high expression in VCR resistant gastric cancer cells.
This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.
zinc ribbon domain containing 1
, DNA-directed RNA polymerase I subunit RPA12
, transcription-associated zinc ribbon protein
, nuclear RNA polymerase I small specific subunit Rpa12 like
, zinc ribbon domain-containing protein 1
, RNA polymerase I small specific subunit Rpa12
, nuclear RNA polymerase I small specific subunit