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The protein encoded by ERMAP is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Additionally we are shipping ERMAP Proteins (12) and ERMAP Kits (6) and many more products for this protein.
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Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
the five known probands with the SC*994C>T silencing nucleotide change were from the Pacific Islands.
The human ermap gene plays an important role in differentiation and development of erythroid cells.
A human cDNA and gene encoding for human ERMAP is cloned and characterized. The protein is sequenced and its expression analyzed.
DNA sequencing demonstrates Scianna antigens including Rd are expressed by ERMAP.
ERMAP, a unique member of the B30.2 domain protein family, is expressed in erythroid cells in fetal liver, adult bone marrow, reticulocytes and in circulating erythroblasts in 8-12-week fetal cord blood.
The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene.
erythroblast membrane-associated protein
, erythroid membrane-associated protein
, Radin blood group (Rd)
, Scianna blood group (Sc)
, radin blood group antigen
, scianna blood group antigen